Idioma:

Ribosome biogenesis in the yeast Saccharomyces cerevisiae

Woolford, Jr, John L ; Baserga, Susan J

Genetics (Austin), 2013-11, Vol.195 (3), p.643-681 [Periódico revisado por pares]

United States: Genetics Society of America

Texto completo disponível

Citações Citado por

Enviar para

Título:
Ribosome biogenesis in the yeast Saccharomyces cerevisiae
Autor: Woolford, Jr, John L ; Baserga, Susan J
Assuntos: Biosynthesis ; Genetic research ; Genomes ; Models, Molecular ; Nucleic Acid Conformation ; Protein Multimerization ; Ribonucleic acid ; Ribosomal Proteins - chemistry ; Ribosomal Proteins - genetics ; Ribosomal Proteins - metabolism ; Ribosomes - genetics ; Ribosomes - metabolism ; RNA ; RNA Precursors - chemistry ; RNA Precursors - genetics ; RNA Precursors - metabolism ; RNA Processing, Post-Transcriptional ; RNA, Fungal - chemistry ; RNA, Fungal - genetics ; RNA, Fungal - metabolism ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - chemistry ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces cerevisiae Proteins - metabolism ; Yeast ; YeastBook
É parte de: Genetics (Austin), 2013-11, Vol.195 (3), p.643-681
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ObjectType-Feature-2
Descrição: Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information in the genome to create the proteome in all cells. In yeast these complex particles contain four RNAs (>5400 nucleotides) and 79 different proteins. During the past 25 years, studies in yeast have led the way to understanding how these molecules are assembled into ribosomes in vivo. Assembly begins with transcription of ribosomal RNA in the nucleolus, where the RNA then undergoes complex pathways of folding, coupled with nucleotide modification, removal of spacer sequences, and binding to ribosomal proteins. More than 200 assembly factors and 76 small nucleolar RNAs transiently associate with assembling ribosomes, to enable their accurate and efficient construction. Following export of preribosomes from the nucleus to the cytoplasm, they undergo final stages of maturation before entering the pool of functioning ribosomes. Elaborate mechanisms exist to monitor the formation of correct structural and functional neighborhoods within ribosomes and to destroy preribosomes that fail to assemble properly. Studies of yeast ribosome biogenesis provide useful models for ribosomopathies, diseases in humans that result from failure to properly assemble ribosomes.
Editor: United States: Genetics Society of America
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Ribosome biogenesis in the yeast Saccharomyces cerevisiae

Woolford, Jr, John L ; Baserga, Susan J

United States: Genetics Society of America

Buscando em bases de dados remotas. Favor aguardar.