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Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea

Kitahara, Cari M ; Berrington de González, Amy ; Freedman, Neal D ; Huxley, Rachel ; Mok, Yejin ; Jee, Sun Ha ; Samet, Jonathan M

Journal of clinical oncology, 2011-04, Vol.29 (12), p.1592-1598 [Periódico revisado por pares]

Alexandria, VA: American Society of Clinical Oncology

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  • Título:
    Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea
  • Autor: Kitahara, Cari M ; Berrington de González, Amy ; Freedman, Neal D ; Huxley, Rachel ; Mok, Yejin ; Jee, Sun Ha ; Samet, Jonathan M
  • Assuntos: Adult ; Aged ; Aged, 80 and over ; Asian People - statistics & numerical data ; Biological and medical sciences ; Biomarkers - blood ; Cholesterol - blood ; Female ; Humans ; Incidence ; Male ; Medical sciences ; Middle Aged ; National Health Programs ; Neoplasms - blood ; Neoplasms - ethnology ; Original Reports ; Proportional Hazards Models ; Prospective Studies ; Republic of Korea - epidemiology ; Risk Assessment ; Risk Factors ; Time Factors ; Tumors
  • É parte de: Journal of clinical oncology, 2011-04, Vol.29 (12), p.1592-1598
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: To further clarify the relationship between total cholesterol and cancer, which remains unclear. We prospectively examined the association between total cholesterol and site-specific and all-cancer incidence among 1,189,719 Korean adults enrolled in the National Health Insurance Corporation who underwent a standardized biennial medical examination in 1992 to 1995 and were observed for 14 years until cancer diagnosis or death. Over follow-up, 53,944 men and 24,475 women were diagnosed with a primary cancer. Compared with levels less than 160 mg/dL, high total cholesterol (≥ 240 mg/dL) was positively associated with prostate cancer (hazard ratio [HR], 1.24; 95% CI, 1.07 to 1.44; P trend = .001) and colon cancer (HR, 1.12; 95% CI, 1.00 to 1.25; P trend = .05) in men and breast cancer in women (HR, 1.17; 95% CI, 1.03 to 1.33; P trend = .03). Higher total cholesterol was associated with a lower incidence of liver cancer (men: HR, 0.42; 95% CI, 0.38 to 0.45; P trend < .001; women: HR, 0.32; 95% CI, 0.27 to 0.39; P trend < .001), stomach cancer (men: HR, 0.87; 95% CI, 0.82 to 0.93; P trend ≤ .001; women: HR, 0.86; 95% CI, 0.77 to 0.97; P trend = .06), and, in men, lung cancer (HR, 0.89; 95% CI, 0.82 to 0.96; P trend < .001). Results for liver cancer were slightly attenuated after additional adjustment for liver enzyme levels and hepatitis B surface antigen status (men: HR, 0.60; P trend < .001; women: HR, 0.46; P trend = .003) and exclusion of the first 10 years of follow-up (men: HR, 0.59; P trend < .001; women: HR, 0.44; P trend < .001). Total cholesterol was inversely associated with all-cancer incidence in both men (HR, 0.84; 95% CI, 0.81 to 0.86; P trend < .001) and women (HR, 0.91; 95% CI, 0.87 to 0.95; P trend < .001), but these associations were attenuated after excluding incident liver cancers (men: HR, 0.95; P trend < .001; women: HR, 0.98; P trend = .32). In this large prospective study, we found that total cholesterol was associated with the risk of several different cancers, although these relationships differed markedly by cancer site.
  • Editor: Alexandria, VA: American Society of Clinical Oncology
  • Idioma: Inglês
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