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Tetrameric Immune Macroglobulins in Three Orders of Bony Fishes

Acton, Ronald T. ; Weinheimer, Peter F. ; Hall, Shelby J. ; Niedermeier, William ; Shelton, Emma ; Bennett, J. Claude

Proceedings of the National Academy of Sciences - PNAS, 1971-01, Vol.68 (1), p.107-111 [Periódico revisado por pares]

United States: National Academy of Sciences of the United States of America

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Título:
Tetrameric Immune Macroglobulins in Three Orders of Bony Fishes
Autor: Acton, Ronald T. ; Weinheimer, Peter F. ; Hall, Shelby J. ; Niedermeier, William ; Shelton, Emma ; Bennett, J. Claude
Assuntos: Amino acids ; Amino Acids - analysis ; Animals ; Biological Sciences: Immunology ; Chemical composition ; Chromatography, Gel ; Disulfides ; Fishes - classification ; Fishes - immunology ; Fucose - analysis ; Galactose - analysis ; Gels ; Glucosamine - analysis ; Humans ; Immunoglobulin M - analysis ; Immunoglobulins ; Immunoglobulins - analysis ; Immunoglobulins - isolation & purification ; Macroglobulins ; Macroglobulins - analysis ; Mannose - analysis ; Microscopy, Electron ; Molecular chains ; Molecular weight ; Molecules ; Neuraminic Acids - analysis ; Sulfides ; Ultracentrifugation
É parte de: Proceedings of the National Academy of Sciences - PNAS, 1971-01, Vol.68 (1), p.107-111
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SourceType-Scholarly Journals-1
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Descrição: The immune IgM-like macroglobulins were isolated from three species of bony fishes (Ictalurus punctatus, Lepisosteus osseus, and Polyodon spathula) representing the three orders of the subclass Actinopterygii. These macroglobulins were found to have sedimentation coefficients of 14 S and molecular weights of 600,000-630,000. The carbohydrate compositions were determined and found to be different from that of human macroglobulins. After reduction and alkylation, the heavy and light chains could be separated by gel filtration and were found to have molecular weights of approximately 70,000 and 23,000 respectively. The amino acid compositions of these chains were similar to those of mammalian IgM heavy and light chains. The macroglobulins were found by electron microscopy to have a tetrameric structure, in contrast to the pentameric structure found in mammalian, chicken, and shark IgM, i.e. in species later on the evolutionary scale.
Editor: United States: National Academy of Sciences of the United States of America
Idioma: Inglês

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Tetrameric Immune Macroglobulins in Three Orders of Bony Fishes

Acton, Ronald T. ; Weinheimer, Peter F. ; Hall, Shelby J. ; Niedermeier, William ; Shelton, Emma ; Bennett, J. Claude

United States: National Academy of Sciences of the United States of America

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