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Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity

Maldonado-Hernández, Jorge ; Saldaña-Dávila, Gabriela E. ; Piña-Aguero, Mónica I. ; Núñez-García, Benjamín A. ; López-Alarcón, Mardia G. Peltekian, Kevork M.

Canadian journal of gastroenterology & hepatology, 2017-01, Vol.2017, p.3689375-6 [Periódico revisado por pares]

Egypt: Hindawi

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Título:
Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity
Autor: Maldonado-Hernández, Jorge ; Saldaña-Dávila, Gabriela E. ; Piña-Aguero, Mónica I. ; Núñez-García, Benjamín A. ; López-Alarcón, Mardia G.
Peltekian, Kevork M.
Assuntos: Adolescent ; Alanine Transaminase - blood ; Aminotransferases ; Apoptosis ; Aspartate Aminotransferases - blood ; Biomarkers ; Biomarkers - blood ; Care and treatment ; Ceramides ; Ceramides - blood ; Diagnosis ; Disease ; Fasting - blood ; Fatty acids ; Fatty Liver - blood ; Fatty Liver - etiology ; Female ; Health aspects ; Humans ; Inflammation ; Insulin - blood ; Insulin resistance ; Liver ; Liver diseases ; Male ; Metabolism ; Methods ; Obesity ; Pediatric Obesity - blood ; Pediatric Obesity - complications ; Pediatrics ; Physiological aspects ; Population ; Predictive Value of Tests ; Rodents ; Sensitivity and Specificity ; Studies ; Teenagers ; Transaminases
É parte de: Canadian journal of gastroenterology & hepatology, 2017-01, Vol.2017, p.3689375-6
Notas: Academic Editor: Kevork M. Peltekian
Descrição: Objective. To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity. Materials and Methods. Ninety-four adolescents from two previous studies conducted and published by our crew were included. Study subjects were stratified in three groups: normal weight (n=18), obesity (n=34), and obesity + HS (n=42). The presence of HS was defined when ALT/AST ratio was <1. Ceramides subspecies (C14:0, C16:0, C18:0, C24:0, and C24:1) were determined by LC/MS. Results. All ceramides correlated directly with ALT levels and inversely with ALT/AST ratio; the strongest correlation was observed among C14:0 ceramide (r=0.41 and r=-0.54, resp.; P<0.001). Furthermore, significant correlations were observed between cholesterol and all ceramides except for C24:1 ceramide. Interestingly ceramides C14:0, C18:0, and C24:1 correlated directly with both fasting insulin and HOMA-IR index. For assessing HS, a cut-off point of 10.3 nmol/L for C14:0 ceramide reported a sensitivity of 92.7% and a specificity of 73.5% when normal weight and obesity groups (n=52) were compared against obesity + HS group (n=42). Positive and negative predictive values were 77.5% and 90.2%, respectively. Conclusions. Plasma ceramides are closely associated with hepatic steatosis in adolescents. C14:0 ceramide could be a novel biomarker of HS independently of obesity.
Editor: Egypt: Hindawi
Idioma: Inglês

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Association between Plasmatic Ceramides Profile and AST/ALT Ratio: C14:0 Ceramide as Predictor of Hepatic Steatosis in Adolescents Independently of Obesity

Maldonado-Hernández, Jorge ; Saldaña-Dávila, Gabriela E. ; Piña-Aguero, Mónica I. ; Núñez-García, Benjamín A. ; López-Alarcón, Mardia G. Peltekian, Kevork M.

Egypt: Hindawi

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