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Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Örebro County and the western region of Sweden

Berglund, Carolina ; Ito, Teruyo ; Ma, Xiao Xue ; Ikeda, Megumi ; Watanabe, Shinya ; Söderquist, Bo ; Hiramatsu, Keiichi

Journal of antimicrobial chemotherapy, 2009-01, Vol.63 (1), p.32-41 [Periódico revisado por pares]

Oxford: Oxford University Press

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Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Örebro County and the western region of Sweden
Autor: Berglund, Carolina ; Ito, Teruyo ; Ma, Xiao Xue ; Ikeda, Megumi ; Watanabe, Shinya ; Söderquist, Bo ; Hiramatsu, Keiichi
Assuntos: Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Bacterial Proteins - genetics ; Bacterial Typing Techniques ; Biological and medical sciences ; Cluster Analysis ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; community-acquired MRSA ; DNA Fingerprinting ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; Drug resistance ; Gene Order ; Genetic Variation ; Genetics ; Genotype ; Human bacterial diseases ; Humans ; Immunologi ; Immunology ; Infectious diseases ; Medical sciences ; MEDICIN ; MEDICINE ; Methicillin-Resistant Staphylococcus aureus - classification ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - isolation & purification ; Microbiology, immunology, infectious diseases ; Mikrobiologi, immunologi, infektionssjukdomar ; Molecular Sequence Data ; MRSA ; Pharmacology. Drug treatments ; Sequence Analysis, DNA ; staphylocoagulase ; staphylococcal cassette chromosome mec ; Staphylococcal Infections - epidemiology ; Staphylococcal Infections - microbiology ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus infections ; Sweden - epidemiology ; Synteny
É parte de: Journal of antimicrobial chemotherapy, 2009-01, Vol.63 (1), p.32-41
Notas: ark:/67375/HXZ-CKFJ4D96-5
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Descrição: Background Recent studies have shown a predominance of type IV SCCmec among the methicillin-resistant Staphylococcus aureus (MRSA) isolated in the low endemic areas of Örebro County and the western region of Sweden. However, many of these isolates were not possible to classify as existing subtypes IVa, IVb, IVc or IVd. Methods We analysed 16 such MRSA isolates by multilocus sequence typing, spa typing, staphylocoagulase (SC) typing and detection of type IVg and IVh SCCmec. MRSA that remained as unknown type IV SCCmec were investigated by long-range PCR covering the J1 region; however, only two isolates were possible to amplify by PCR. The nucleotide sequences of the entire SCCmec of these two MRSA were determined. In addition, isolates that had unknown SC types were investigated by nucleotide sequencing of the coa genes. Results Five of 16 isolates were classified as type IVg SCCmec, and four isolates had type IVh SCCmec. Two subtypes of type IV SCCmec shared J1 regions previously identified in other types of SCCmec, types I.2 and II.2. The novel elements were designated as type IVi and IVj SCCmec. In addition, the genetic backgrounds of these Swedish MRSA were diverse and constituted at least nine sequence types and eight SC types, including four new types of SC. Conclusions Type IV SCCmec is occurring in heterogeneous clones of MRSA in Sweden, and the majority of the type IV SCCmec were identified in community-acquired MRSA. We describe two novel subtypes of type IV SCCmec with common J1 regions shared by other types of SCCmec, which indicate that J1 regions occurred as primordial SCC.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Genetic diversity of methicillin-resistant Staphylococcus aureus carrying type IV SCCmec in Örebro County and the western region of Sweden

Berglund, Carolina ; Ito, Teruyo ; Ma, Xiao Xue ; Ikeda, Megumi ; Watanabe, Shinya ; Söderquist, Bo ; Hiramatsu, Keiichi

Oxford: Oxford University Press

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