skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Can antioxidants protect against chemotherapy in a rat spermatogonial stem cell line?

Allen, Caroline M ; Lopes, Federica ; Mitchell, Rod T ; Spears, Norah

Reproduction & fertility, 2021-12, Vol.2 (4), p.L7-L9 [Periódico revisado por pares]

England: Bioscientifica Ltd

Texto completo disponível

Citações Citado por
  • Título:
    Can antioxidants protect against chemotherapy in a rat spermatogonial stem cell line?
  • Autor: Allen, Caroline M ; Lopes, Federica ; Mitchell, Rod T ; Spears, Norah
  • Assuntos: antioxidants ; chemotherapy ; fertility preservation ; Research Letter ; spermatogonial stem cells
  • É parte de: Reproduction & fertility, 2021-12, Vol.2 (4), p.L7-L9
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    F Lopes is now at School of Medicine, University of Dundee, Dundee, UK
    C M Allen is now at School of Life Sciences, University of Glasgow, Glasgow, UK
  • Descrição: Boys administered chemotherapy to treat cancer are at risk of damage to their healthy testicular tissue, which can lead to infertility in adulthood. Researchers are therefore investigating treatments to protect the testis during cancer treatment. Here, cells originating from rat testicles were cultured for 4 days and exposed to chemotherapy drugs with or without antioxidants for the final 2 days. Antioxidants can reduce cellular damage by inactivating toxic compounds. Here, antioxidants such as melatonin or -acetylcysteine were tested against chemotherapy agents cisplatin, doxorubicin, or vincristine. Cultures were repeated four times, with cell survival measured at the end of culture. The antioxidants were not damaging and partially protected against cisplatin, although not doxorubicin. Surprisingly, -acetylcysteine enhanced vincristine-induced damage. The results suggest that using antioxidants to protect the testis could have either beneficial or harmful effects when given alongside different chemotherapy drugs: this is important, considering that patients are often treated with multiple drugs.
  • Editor: England: Bioscientifica Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.