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Role of the thalamus in natural recovery of cognitive impairment in patients with mild traumatic brain injury

Munivenkatappa, Ashok ; Devi, Bhagavatula Indira ; Shukla, Dhaval P. ; Rajeswaran, Jamuna

Brain injury, 2016-03, Vol.30 (4), p.388-392 [Periódico revisado por pares]

England: Taylor & Francis

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Título:
Role of the thalamus in natural recovery of cognitive impairment in patients with mild traumatic brain injury
Autor: Munivenkatappa, Ashok ; Devi, Bhagavatula Indira ; Shukla, Dhaval P. ; Rajeswaran, Jamuna
Assuntos: Adult ; attention ; Brain Injuries, Traumatic - complications ; Brain Injuries, Traumatic - diagnostic imaging ; Cognition Disorders - diagnostic imaging ; Cognition Disorders - etiology ; cognitive scores ; Diffusion Tensor Imaging ; Female ; Glasgow Coma Scale ; Humans ; Image Processing, Computer-Assisted ; Male ; memory ; Mild traumatic brain injury ; natural recovery ; Neuropsychological Tests ; Recovery of Function - physiology ; tensor changes ; Thalamus - diagnostic imaging ; Thalamus - physiopathology ; Time Factors ; volume changes ; Young Adult
É parte de: Brain injury, 2016-03, Vol.30 (4), p.388-392
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Introduction: Patients with mild traumatic brain injury (mTBI) may have normal neuroimaging but manifest with a broad-spectrum of cognitive-deficits, which may resolve eventually. The function of the thalamus in the process of natural-recovery remains elusive. The current study investigates the role of the thalamus in natural-recovery of cognitive-deficits in patients with mTBI. Methods: Twenty-one patients with mTBI were evaluated with an initial MRI scan, within 36 hours of injury and assessed with neuropsychological tests(NPT) at 3-4 weeks after injury. First and second follow-up MRI and NPT were performed at 3-4 months and 6-7 months, respectively. The volume and tensor measures of the thalamus and cognitive-scores were analysed at each assessment using repeated-measures of variance. The association of cognitive-scores with corresponding period imaging measures was analysed using bivariate-correlation. Results: Serial evaluation showed that all the cognitive-domains improved significantly. During this period there was a significant increase in mean thalamic volume (p = 0.049, effect-size = 0.18). After 3-4 months there was emergence of anisotropic thalamo-cortical connections. At 2-3 weeks and 6-7 months after injury, the alterations in diffusivity values were positively associated with improvement in memory-scores. Improvement in attention-scores correlated significantly with changes in tensor values at the 6-7 months after-injury. Conclusion: The correlation between improvement in cognitive-scores and changes in thalamic tensor and volume measures reflect the role of the thalamus in natural-recovery after mTBI.
Editor: England: Taylor & Francis
Idioma: Inglês

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Role of the thalamus in natural recovery of cognitive impairment in patients with mild traumatic brain injury

Munivenkatappa, Ashok ; Devi, Bhagavatula Indira ; Shukla, Dhaval P. ; Rajeswaran, Jamuna

England: Taylor & Francis

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