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The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes

Hollis, Bruce W ; Wagner, Carol L

The journal of clinical endocrinology and metabolism, 2013-12, Vol.98 (12), p.4619-4628 [Periódico revisado por pares]

Bethesda, MD: Endocrine Society

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  • Título:
    The Role of the Parent Compound Vitamin D with Respect to Metabolism and Function: Why Clinical Dose Intervals Can Affect Clinical Outcomes
  • Autor: Hollis, Bruce W ; Wagner, Carol L
  • Assuntos: Biological and medical sciences ; Endocrinopathies ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Medical sciences ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology
  • É parte de: The journal of clinical endocrinology and metabolism, 2013-12, Vol.98 (12), p.4619-4628
  • Notas: This work was funded in part by the National Institute of Child Health and Human Development (Grants R01 HD043921 and HD47511); National Institutes of Health (NIH) Grant RR01070; the South Carolina Clinical and Translational Research Institute, with an academic home at the Medical University of South Carolina; NIH/National Center for Research Resources Grant UL1 RR029882; National Center for Advancing Translational Sciences Grant UL1 TR000062; the Thrasher Research Fund; and the Kellogg Foundation.
  • Descrição: Context: There is no doubt that vitamin D must be activated to the hormonal form 1,25-dihydroxyvitamin D to achieve full biological activity or that many tissues participate in this activation process—be it endocrine or autocrine. We believe that not only is 25-hydroxyvitamin D important to tissue delivery for this activation process, but also that intact vitamin D has a pivotal role in this process. Objective: In this review, evidence on the vitamin D endocrine/autocrine system is presented and discussed in relation to vitamin D-binding protein affinity, circulating half-lives, and enzymatic transformations of vitamin D metabolites, and how these affect biological action in any given tissue. Conclusions: Circulating vitamin D, the parent compound, likely plays an important physiological role with respect to the vitamin D endocrine/autocrine system, as a substrate in many tissues, not originally thought to be important. Based on emerging data from the laboratory, clinical trials, and data on circulating 25-hydroxyvitamin D amassed during many decades, it is likely that for the optimal functioning of these systems, significant vitamin D should be available on a daily basis to ensure stable circulating concentrations, implying that variation in vitamin D dosing schedules could have profound effects on the outcomes of clinical trials because of the short circulating half-life of intact vitamin D.
  • Editor: Bethesda, MD: Endocrine Society
  • Idioma: Inglês
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