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Prevalence of Human Papillomavirus Infection in Women in Portugal: The CLEOPATRE Portugal Study

Pista, Angela ; de Oliveira, Carlos Freire ; Cunha, Maria João ; Paixao, Maria Teresa ; Real, Odete

International journal of gynecological cancer, 2011-08, Vol.21 (6), p.1150-1158 [Periódico revisado por pares]

England: Copyright by IGCS and ESGO

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  • Título:
    Prevalence of Human Papillomavirus Infection in Women in Portugal: The CLEOPATRE Portugal Study
  • Autor: Pista, Angela ; de Oliveira, Carlos Freire ; Cunha, Maria João ; Paixao, Maria Teresa ; Real, Odete
  • Assuntos: Adolescent ; Adult ; Age Factors ; Cellular biology ; Cross-Sectional Studies ; Female ; Human papillomavirus ; Humans ; Infections ; Middle Aged ; Papillomaviridae - classification ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - epidemiology ; Papillomavirus Infections - virology ; Portugal - epidemiology ; Prevalence ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - virology ; Womens health ; Young Adult
  • É parte de: International journal of gynecological cancer, 2011-08, Vol.21 (6), p.1150-1158
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Objective:Human papillomavirus (HPV) is responsible for a range of diseases, including cervical cancer. The primary objectives of the CLEOPATRE Portugal study were to estimate the overall and age-stratified prevalence of cervical HPV infection and to assess HPV prevalence and type-specific distribution by cytological results among women aged 18 to 64 years, who reside in mainland Portugal.Materials and Methods:This cross-sectional population-based study recruited women aged 18 to 64 years, according to an age-stratified sampling strategy, who attended gynecology/obstetrics or sexually transmitted disease clinics across the 5 regional health administrations in mainland Portugal between 2008 and 2009. Liquid-based cytology samples were collected and analyzed centrally for HPV genotyping (clinical array HPV 2 assay) and cytology. Prevalence estimates were adjusted for age using 2007 Portuguese census data.Results:A total of 2326 women were included in the study. The overall prevalence of HPV infection in the study was 19.4% (95% confidence interval, 17.8%-21.0%), with the highest prevalence in women aged 18 to 24 years. High-risk HPV types were detected in 76.5% of infections, of which 36.6% involved multiple types. The commonest high-risk type was HPV-16. At least 1 of the HPV types 6/11/16/18 was detected in 32.6% of infections. The HPV prevalence in normal cytology samples was 16.5%. There was a statistically significant association between high-risk infection and cytological abnormalities (P < 0.001).Conclusions:This is the first population-based study to quantify and describe cervical HPV infection in mainland Portugal. This study provides baseline data for future assessment of the impact of HPV vaccination programs.
  • Editor: England: Copyright by IGCS and ESGO
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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