Idioma:

Prognostic role of blood KL-6 in rheumatoid arthritis-associated interstitial lung disease

Kim, Ho Cheol ; Choi, Kwang Hun ; Jacob, Joseph ; Song, Jin Woo Kuwana, Masataka

PloS one, 2020-03, Vol.15 (3), p.e0229997-e0229997 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por

Enviar para

Título:
Prognostic role of blood KL-6 in rheumatoid arthritis-associated interstitial lung disease
Autor: Kim, Ho Cheol ; Choi, Kwang Hun ; Jacob, Joseph ; Song, Jin Woo
Kuwana, Masataka
Assuntos: Age ; Age Factors ; Aged ; Analysis ; Arthritis ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - pathology ; Biological markers ; Biology and Life Sciences ; Biomarkers ; Biomarkers - blood ; Biopsy ; Blood ; Carbon monoxide ; CAT scans ; Computed tomography ; Critical care ; Development and progression ; Diseases ; Female ; Humans ; Idiopathic Pulmonary Fibrosis - complications ; Idiopathic Pulmonary Fibrosis - pathology ; Latex ; Levels ; Logistic Models ; Lung - physiology ; Lung diseases ; Lung Diseases, Interstitial - etiology ; Lung Diseases, Interstitial - mortality ; Lung Diseases, Interstitial - pathology ; Lung volume measurement ; Male ; Male identity ; Medical prognosis ; Medical records ; Medicine ; Medicine and Health Sciences ; Men ; Middle Aged ; Mortality ; Mucin-1 - blood ; Multivariate analysis ; Odds Ratio ; Patients ; Physical Sciences ; Pneumonia ; Prognosis ; Proportional Hazards Models ; Pulmonary fibrosis ; Regression analysis ; Respiratory tract diseases ; Retrospective Studies ; Rheumatoid arthritis ; Rheumatoid factor ; Smokers ; Smoking ; Studies ; Survival analysis ; Survival Rate ; Tomography ; Tomography, X-Ray Computed ; Variables ; Vital Capacity
É parte de: PloS one, 2020-03, Vol.15 (3), p.e0229997-e0229997
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: JWS reports provided reagents for KL-6 from Kyung Il Medical Inc. and JJ reports personal fees from Boehringer Ingelheim outside the current work. There are no patents, products in development or marketed products to declare. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
Descrição: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) has a variable clinical course for which predicting prognosis is difficult. However, the role of blood biomarkers in RA-ILD is ill-defined. The aim of this study was to investigate the prognostic value of Krebs von den Lungen-6 (KL-6) levels in RA-ILD patients. The medical records of 84 patients with RA-ILD were retrospectively reviewed. Plasma KL-6 levels were measured by Nanopia KL-6 assay (SEKISUI MEDICAL, Tokyo), using latex-enhanced immunoturbidimetric assay. The median follow-up period was 61 months. Mean age was 61.4 years, 45.2% were men, 44.0% were ever-smokers, and 35.7% showed a usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography. The median KL-6 level at baseline was 741.2 U/mL (interquartile range, 439.7-1308.9 U/mL). On multivariate logistic regression analysis, a high KL-6 level (≥ 640 U/mL) was an independently associated with a UIP pattern (odds ratio [OR], 5.173; P = 0.005) with old age (OR, 1.104, P = 0.005). On multivariate Cox analysis, a high KL-6 level (≥ 685 U/mL) was an independent prognostic factor for the mortality (hazard ratio [HR], 2.984; P = 0.016) with a older age (HR, 1.061; P = 0.030), male sex (HR, 3.610; P = 0.001), lower forced vital capacity (HR, 0.957; P = 0.002), and a UIP pattern (HR, 4.034; P = 0.002). Our results suggest that high KL-6 levels might be useful as a biomarker for the presence of a UIP pattern and prognosis in patients with RA-ILD.
Editor: United States: Public Library of Science
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Prognostic role of blood KL-6 in rheumatoid arthritis-associated interstitial lung disease

Kim, Ho Cheol ; Choi, Kwang Hun ; Jacob, Joseph ; Song, Jin Woo Kuwana, Masataka

United States: Public Library of Science

Buscando em bases de dados remotas. Favor aguardar.