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Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation

KANDA, J ; HORWITZ, M. E ; RIZZIERI, D. A ; LONG, G. D ; GASPARETTO, C ; SULLIVAN, K. M ; CHUTE, J. P ; MORRIS, A ; HENNIG, T ; LI, Z ; CHAO, N. J

Bone marrow transplantation (Basingstoke), 2012-05, Vol.47 (5), p.700-705 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Título:
Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation
Autor: KANDA, J ; HORWITZ, M. E ; RIZZIERI, D. A ; LONG, G. D ; GASPARETTO, C ; SULLIVAN, K. M ; CHUTE, J. P ; MORRIS, A ; HENNIG, T ; LI, Z ; CHAO, N. J
Assuntos: Adult ; Age ; Aged ; Alemtuzumab ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibodies, Monoclonal, Humanized - therapeutic use ; Biological and medical sciences ; Blood diseases ; Bone marrow ; Bone marrow transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Care and treatment ; Cyclophosphamide ; Cyclophosphamide - therapeutic use ; Development and progression ; Donors ; Failure ; Female ; Fludarabine ; Graft Survival ; Graft versus host reaction ; Graft vs Host Disease - prevention & control ; Grafting ; Grafts ; Health aspects ; Health risks ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic stem cells ; Hemopoiesis ; Humans ; Infection ; Infection control ; Leukocytes (neutrophilic) ; Lymphocytes T ; Male ; Medical sciences ; Middle Aged ; Monoclonal antibodies ; Patient outcomes ; Rejection ; Remission ; Reoperation ; Retrospective Studies ; Risk factors ; Salvage Therapy - methods ; Siblings ; Stem cell transplantation ; T cells ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation ; Transplantation Conditioning - methods ; Transplantation, Homologous - adverse effects ; Vidarabine - analogs & derivatives ; Vidarabine - therapeutic use
É parte de: Bone marrow transplantation (Basingstoke), 2012-05, Vol.47 (5), p.700-705
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: Primary graft failure after allogeneic hematopoietic cell transplantation is a life-threatening complication. A shortened conditioning regimen may reduce the risk of infection and increase the chance of survival. Here, we report the outcome of 11 patients with hematologic diseases (median age, 44; range, 25-67 years, seven males) who received a 1-day reduced-intensity preparative regimen given as a re-transplantation for primary graft failure. The salvage regimen consisted of fludarabine, cyclophosphamide, alemtuzumab and TBI, all administered 1 day before re-transplantation. All patients received T-cell replete PBSCs from the same or a different haploidentical donor (n=10) or from the same matched sibling donor (n=1). Neutrophil counts promptly increased to >500/μL for 10 of the 11 patients at a median of 13 days. Of these, none developed grade III/IV acute GVHD. At present, 8 of the 11 patients are alive with a median follow-up of 11.2 months from re-transplantation and 5 of the 8 are in remission. In conclusion, this series suggests that our 1-day preparative regimen is feasible, leads to successful engraftment in a high proportion of patients, and is appropriate for patients requiring immediate re-transplantation after primary graft failure following reduced-intensity transplantation.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation

KANDA, J ; HORWITZ, M. E ; RIZZIERI, D. A ; LONG, G. D ; GASPARETTO, C ; SULLIVAN, K. M ; CHUTE, J. P ; MORRIS, A ; HENNIG, T ; LI, Z ; CHAO, N. J

Basingstoke: Nature Publishing Group

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