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Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

Folkerts, Gert ; Van der Linde, Henk ; Van de Loo, Peet G.F. ; Engels, Ferdi ; Nijkamp, Frans P.

European journal of pharmacology, 1995-10, Vol.285 (2), p.R1-R2 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition
Autor: Folkerts, Gert ; Van der Linde, Henk ; Van de Loo, Peet G.F. ; Engels, Ferdi ; Nijkamp, Frans P.
Assuntos: Animals ; Arginine - analogs & derivatives ; Arginine - pharmacology ; Benzoquinones - pharmacology ; Biological and medical sciences ; Chromones - pharmacology ; Cyclooxygenase Inhibitors - pharmacology ; Enzyme Inhibitors - pharmacology ; Guinea pig ; Guinea Pigs ; In Vitro Techniques ; Leukotriene ; Leukotrienes - physiology ; Lipoxygenase Inhibitors - pharmacology ; Medical sciences ; NG-Nitroarginine Methyl Ester ; Nitric oxide (NO) ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase - antagonists & inhibitors ; Pneumology ; Respiratory system : syndromes and miscellaneous diseases ; Trachea - drug effects ; Trachea - physiology ; Tracheal hyperresponsiveness
É parte de: European journal of pharmacology, 1995-10, Vol.285 (2), p.R1-R2
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Preincubation of guinea pig tracheas with the nitric oxide synthase inhibitor, N ω-nitro- l-arginine methyl ester (L-NAME, 120 μM) resulted in a significant upward shift of the histamine concentration-response curve with a concomitant inhibition of prostaglandin E 2 production. Preincubation of the preparations with a 5-lipoxygenase inhibitor (AA-861, 2-(12-hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl- p-benoquinone) or a leukotriene C 4,D 4,E 4 receptor antagonist (FPL 55712, sodium 7-{3-(4-acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxy propoxy}-4-oxo-8-propyl-4 H-1-benzopyran-2-carboxylate) totally blocked the L-NAME-induced tracheal hyperresponsiveness. A shift from cyclo-oxygenase to lipoxygenase products, in particular leukotrienes, is likely to be responsible for the L-NAME-induced tracheal hyperresponsiveness.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition

Folkerts, Gert ; Van der Linde, Henk ; Van de Loo, Peet G.F. ; Engels, Ferdi ; Nijkamp, Frans P.

Amsterdam: Elsevier B.V

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