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Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients

Sun, Wei ; Shen, Xuehua ; Wang, Jing ; Zhu, Shuangshuang ; Zhang, Yanting ; Wu, Chun ; Xie, Yuji ; Yang, Yun ; Dong, Nianguo ; Wang, Guohua ; Li, Yuman ; Lv, Qing ; Liang, Bo ; Zhang, Li ; Xie, Mingxing

Frontiers in cardiovascular medicine, 2021-11, Vol.8, p.727745-727745 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Association Between 2D- and 3D-Speckle-Tracking Longitudinal Strain and Cardiovascular Magnetic Resonance Evidence of Diffuse Myocardial Fibrosis in Heart Transplant Recipients
  • Autor: Sun, Wei ; Shen, Xuehua ; Wang, Jing ; Zhu, Shuangshuang ; Zhang, Yanting ; Wu, Chun ; Xie, Yuji ; Yang, Yun ; Dong, Nianguo ; Wang, Guohua ; Li, Yuman ; Lv, Qing ; Liang, Bo ; Zhang, Li ; Xie, Mingxing
  • Assuntos: cardiovascular magnetic resonance ; Cardiovascular Medicine ; diffuse myocardial fibrosis ; extracellular volume fraction ; heart transplant ; speckle tracking echocardiography
  • É parte de: Frontiers in cardiovascular medicine, 2021-11, Vol.8, p.727745-727745
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Reviewed by: Ali Hosseinsabet, Tehran University of Medical Sciences, Iran; Lennart Tautz, Charité—Universitätsmedizin Berlin, Germany
    This article was submitted to Cardiovascular Imaging, a section of the journal Frontiers in Cardiovascular Medicine
    These authors have contributed equally to this work and share first authorship
    Edited by: Juan Carlos Del Alamo, University of Washington, United States
  • Descrição: This study aimed to: (1) evaluate the association between myocardial fibrosis (MF) quantified by extracellular volume fraction (ECV) and myocardial strain measured by two-dimensional (2D)- and three-dimensional speckle-tracking echocardiography (3D-STE) and (2) further investigate which strain parameter measured by 2D- and 3D-STE is the more robust predictor of MF in heart transplant (HT) recipients. A total of 40 patients with HT and 20 healthy controls were prospectively enrolled. Left ventricular (LV)-global longitudinal strain (GLS), global circumferential strain (GCS), and global radial strain (GRS) were measured by 2D- and 3D-STE. LV diffuse MF was defined by cardiovascular magnetic resonance (CMR)-ECV. The HT recipients had a significantly higher native T1 and ECV than healthy controls (1043.8 ± 34.0 vs. 999.7 ± 19.7 ms, < 0.001; 26.6 ± 2.7 vs. 24.3 ± 1.8%, = 0.02). The 3D- and 2D-STE-LVGLS and LVGCS were lower ( < 0.005) in the HT recipients than in healthy controls. ECV showed a moderate correlation with 2D-LVGLS ( = 0.53, = 0.002) and 3D-LVGLS ( = 0.60, < 0.001), but it was not correlated with 2D or 3D-LVGCS, or LVGRS. Furthermore, 3D-LVGLS and 2D-LVGLS had a similar correlation with CMR-ECV ( = 0.60 vs. 0.53, = 0.670). A separate stepwise multivariate linear analysis showed that both the 2D-LVGLS (β = 0.39, = 0.019) and 3D-LVGLS (β = 0.54, < 0.001) were independently associated with CMR-ECV. CMR marker of diffuse MF was present in asymptomatic patients with HT and appeared to be associated with decreased myocardial strain by echocardiography. Both the 2D- and 3D-LVGLS were independently correlated with diffuse LVMF, which may provide an alternative non-invasive tool for monitoring the development of adverse fibrotic remodeling during the follow-up of HT recipients.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês

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