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Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

Barrie, William ; Yang, Yaoling ; Irving-Pease, Evan K ; Attfield, Kathrine E ; Scorrano, Gabriele ; Jensen, Lise Torp ; Armen, Angelos P ; Dimopoulos, Evangelos Antonios ; Stern, Aaron ; Refoyo-Martinez, Alba ; Pearson, Alice ; Ramsøe, Abigail ; Gaunitz, Charleen ; Demeter, Fabrice ; Jørkov, Marie Louise S ; Møller, Stig Bermann ; Springborg, Bente ; Klassen, Lutz ; Hyldgård, Inger Marie ; Wickmann, Niels ; Vinner, Lasse ; Korneliussen, Thorfinn Sand ; Allentoft, Morten E ; Sikora, Martin ; Kristiansen, Kristian ; Rodriguez, Santiago ; Nielsen, Rasmus ; Iversen, Astrid K N ; Lawson, Daniel J ; Fugger, Lars ; Willerslev, Eske

Nature (London), 2024, Vol.625 (7994), p.321-328 [Periódico revisado por pares]

England: Nature Publishing Group UK

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Título:
Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations
Autor: Barrie, William ; Yang, Yaoling ; Irving-Pease, Evan K ; Attfield, Kathrine E ; Scorrano, Gabriele ; Jensen, Lise Torp ; Armen, Angelos P ; Dimopoulos, Evangelos Antonios ; Stern, Aaron ; Refoyo-Martinez, Alba ; Pearson, Alice ; Ramsøe, Abigail ; Gaunitz, Charleen ; Demeter, Fabrice ; Jørkov, Marie Louise S ; Møller, Stig Bermann ; Springborg, Bente ; Klassen, Lutz ; Hyldgård, Inger Marie ; Wickmann, Niels ; Vinner, Lasse ; Korneliussen, Thorfinn Sand ; Allentoft, Morten E ; Sikora, Martin ; Kristiansen, Kristian ; Rodriguez, Santiago ; Nielsen, Rasmus ; Iversen, Astrid K N ; Lawson, Daniel J ; Fugger, Lars ; Willerslev, Eske
Assuntos: Datasets as Topic ; Diet - ethnology ; Diet - history ; Europe - ethnology ; Genetic Predisposition to Disease - history ; Genetics, Medical ; Genome, Human ; Grassland ; Historia och arkeologi ; History and Archaeology ; History, 15th Century ; History, Ancient ; History, Medieval ; Human Migration - history ; Humans ; Life Style - ethnology ; Life Style - history ; Multiple Sclerosis - genetics ; Multiple Sclerosis - history ; Multiple Sclerosis - immunology ; Neurodegenerative Diseases - genetics ; Neurodegenerative Diseases - history ; Neurodegenerative Diseases - immunology ; Population Density
É parte de: Nature (London), 2024, Vol.625 (7994), p.321-328
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated . Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age , along with new Medieval and post-Medieval genomes, we show that the genetic risk for MS rose among pastoralists from the Pontic steppe and was brought into Europe by the Yamnaya-related migration approximately 5,000 years ago. We further show that these MS-associated immunogenetic variants underwent positive selection both within the steppe population and later in Europe, probably driven by pathogenic challenges coinciding with changes in diet, lifestyle and population density. This study highlights the critical importance of the Neolithic period and Bronze Age as determinants of modern immune responses and their subsequent effect on the risk of developing MS in a changing environment.
Editor: England: Nature Publishing Group UK
Idioma: Inglês

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Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations

England: Nature Publishing Group UK

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