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Initial antimicrobial management of sepsis

Niederman, Michael S ; Baron, Rebecca M ; Bouadma, Lila ; Calandra, Thierry ; Daneman, Nick ; DeWaele, Jan ; Kollef, Marin H ; Lipman, Jeffrey ; Nair, Girish B

Critical care (London, England), 2021-08, Vol.25 (1), p.307-307, Article 307 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Initial antimicrobial management of sepsis
Autor: Niederman, Michael S ; Baron, Rebecca M ; Bouadma, Lila ; Calandra, Thierry ; Daneman, Nick ; DeWaele, Jan ; Kollef, Marin H ; Lipman, Jeffrey ; Nair, Girish B
Assuntos: Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - therapeutic use ; Antibiotic therapy ; Antibiotics ; Antimicrobial agents ; Antimicrobial therapy ; Bacterial infections ; Biomarkers ; Biomarkers - analysis ; Biomarkers - blood ; Diagnosis ; Dosage and administration ; Drug therapy ; E coli ; Fungal infection ; Humans ; Intra-abdominal infection ; Microorganisms ; Mortality ; Pathogens ; Patients ; Pneumonia ; Review ; Sepsis ; Sepsis - drug therapy ; Staphylococcus infections ; Streptococcus infections ; Time Factors ; Time-to-Treatment - standards ; Time-to-Treatment - statistics & numerical data ; Urinary tract infections
É parte de: Critical care (London, England), 2021-08, Vol.25 (1), p.307-307, Article 307
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Sepsis is a common consequence of infection, associated with a mortality rate > 25%. Although community-acquired sepsis is more common, hospital-acquired infection is more lethal. The most common site of infection is the lung, followed by abdominal infection, catheter-associated blood steam infection and urinary tract infection. Gram-negative sepsis is more common than gram-positive infection, but sepsis can also be due to fungal and viral pathogens. To reduce mortality, it is necessary to give immediate, empiric, broad-spectrum therapy to those with severe sepsis and/or shock, but this approach can drive antimicrobial overuse and resistance and should be accompanied by a commitment to de-escalation and antimicrobial stewardship. Biomarkers such a procalcitonin can provide decision support for antibiotic use, and may identify patients with a low likelihood of infection, and in some settings, can guide duration of antibiotic therapy. Sepsis can involve drug-resistant pathogens, and this often necessitates consideration of newer antimicrobial agents.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Initial antimicrobial management of sepsis

Niederman, Michael S ; Baron, Rebecca M ; Bouadma, Lila ; Calandra, Thierry ; Daneman, Nick ; DeWaele, Jan ; Kollef, Marin H ; Lipman, Jeffrey ; Nair, Girish B

England: BioMed Central Ltd

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