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Comparison of Binding and Activity of 8-Alkyl-Pterins and 8-Alkyl-N5-Deaza-Pterins with Dihydrofolate Reductase

Ivery, Michael T. G. ; Gready, Jill E.

Advances in experimental medicine and biology, 1993, Vol.338, p.525-528 [Periódico revisado por pares]

Boston, MA: Springer US

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Título:
Comparison of Binding and Activity of 8-Alkyl-Pterins and 8-Alkyl-N5-Deaza-Pterins with Dihydrofolate Reductase
Autor: Ivery, Michael T. G. ; Gready, Jill E.
Assuntos: Alkylation ; Animals ; Binary Complex ; Binding Cooperativity ; Chicken Liver ; Chickens ; Folic Acid Antagonists - metabolism ; Folic Acid Antagonists - pharmacology ; Human Enzyme ; Humans ; Kinetics ; Molecular Structure ; Pterins - metabolism ; Pterins - pharmacology ; Structure-Activity Relationship ; Ternary Complex ; Tetrahydrofolate Dehydrogenase - chemistry ; Tetrahydrofolate Dehydrogenase - metabolism ; Thermodynamics
É parte de: Advances in experimental medicine and biology, 1993, Vol.338, p.525-528
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The 8-alkyl-pterins 1 and 8-alkyl-N5-deaza-pterins 2 constitute two new classes of mechanism-based substrates and inhibitors, respectively, for the enzyme dihydrofolate reductase.
Editor: Boston, MA: Springer US
Idioma: Inglês

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