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Polymer particles that switch shape in response to a stimulus

Yoo, Jin-Wook ; Mitragotri, Samir ; Tirrell, David A.

Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (25), p.11205-11210 [Periódico revisado por pares]

United States: National Academy of Sciences

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Título:
Polymer particles that switch shape in response to a stimulus
Autor: Yoo, Jin-Wook ; Mitragotri, Samir ; Tirrell, David A.
Assuntos: Animals ; Biocompatible Materials - chemistry ; Biomedical engineering ; Biomedical materials ; Cells ; Cellular biology ; Drug Carriers ; Drug Delivery Systems ; Equipment Design ; Geometric shapes ; Interfacial tension ; Macrophages ; Macrophages - metabolism ; Materials Testing ; Mice ; Microscopy, Electron, Scanning - methods ; Microscopy, Video - methods ; Nanoparticles ; Particle interactions ; Particle mass ; Particle Size ; Phagocytosis ; Physical Sciences ; Polymers ; Polymers - chemistry ; Time Factors ; Viscosity
É parte de: Proceedings of the National Academy of Sciences - PNAS, 2010-06, Vol.107 (25), p.11205-11210
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Author contributions: J.-W.Y. and S.M. designed research; J.-W.Y. performed research; J.-W.Y. contributed new reagents/analytic tools; J.-W.Y. and S.M. analyzed data; and J.-W.Y. and S.M. wrote the paper.
Edited* by David A. Tirrell, California Institute of Technology, Pasadena, CA, and approved May 14, 2010 (received for review January 10, 2010)
Descrição: Particle engineering for biomedical applications has unfolded the roles of attributes such as size, surface chemistry, and shape for modulating particle interactions with cells. Recently, dynamic manipulation of such key properties has gained attention in view of the need to precisely control particle interaction with cells. With increasing recognition of the pivotal role of particle shape in determining their biomedical applications, we report on polymeric particles that are able to switch their shape in real time in a stimulus-responsive manner. The shape-switching behavior was driven by a subtle balance between polymer viscosity and interfacial tension. The balance between the two forces was modulated by application of an external stimulus chosen from temperature, pH, or chemical additives. The dynamics of shape switch was precisely controlled over minutes to days under physiological conditions. Shape-switching particles exhibited unique interactions with cells. Elliptical disk-shaped particles that are not phagocytosed by macrophages were made to internalize through shape switch, demonstrating the ability of shape-switchable particles in modulating interaction with cells.
Editor: United States: National Academy of Sciences
Idioma: Inglês

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Polymer particles that switch shape in response to a stimulus

Yoo, Jin-Wook ; Mitragotri, Samir ; Tirrell, David A.

United States: National Academy of Sciences

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