Cathepsin S as a target in gastric cancer

• Autor: da Costa, Adriano Carneiro ; Santa-Cruz, Fernando ; Mattos, Luiz Alberto Reis ; Rêgo Aquino, Maria Améllia ; Martins, Camila Ramos ; Bandeira Ferraz, Álvaro Antônio ; Figueiredo, José Luiz
• Assuntos: Angiogenesis ; Anopheles ; Apoptosis ; Autophagy ; Biological markers ; Breast cancer ; Cancer ; Cancer metastasis ; Cancer therapies ; Carcinogenesis ; Cathepsins ; Cell adhesion & migration ; Development and progression ; Epidermal growth factor ; Gastric cancer ; Gastrointestinal tumors ; Kinases ; Liver cancer ; Mediation ; Medical prognosis ; Metastasis ; Mortality ; Novels ; Oncology ; Recurrence (Disease) ; Review ; Stomach cancer ; Tumors ; Vascular endothelial growth factor
• É parte de: Molecular and clinical oncology, 2020-02, Vol.12 (2), p.99-103
• Notas: Dr Fernando Santa-Cruz, Centro de Ciências Médicas, Universidade Federal de Pernambuco, 1235 Av. Prof. Moraes Rego, Cidade Universitária, Recife, PE 50670-901, Brazil E-mail:f.santacruzoliveira@gmail.com
  
• Descrição: Cathepsin S (Cat S) is a protein expressed in some epithelial cells, which appears to be associated with cancer metastasis and recurrence. The abnormal expression of Cat S has been reported to be associated with the progression of certain types of gastrointestinal neoplasms, including gastric cancer (GC). There is a need to identify novel biomarkers and therapeutic targets associated with the growth, invasion and migration of GC cells, in order to develop non-invasive diagnostic and prognostic procedures and design new therapeutic approaches. The aim of the present study was to assess the association between Cat S and oncogenic processes implicated in the development of GC, focusing on the diagnostic and therapeutic potential of this molecule in GC. A search was conducted through the PubMed and Cochrane Central Register of Controlled Trials electronic databases for relevant literature published between 2003 and 2018, using the mesh terms 'cathepsin S' and 'cancer' and 'gastric cancer'.
  
• Editor: England: Spandidos Publications
  
• Idioma: Inglês