Idioma:

Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial

Paci, Eugenio ; Puliti, Donella ; Lopes Pegna, Andrea ; Carrozzi, Laura ; Picozzi, Giulia ; Falaschi, Fabio ; Pistelli, Francesco ; Aquilini, Ferruccio ; Ocello, Cristina ; Zappa, Marco ; Carozzi, Francesca M ; Mascalchi, Mario

Thorax, 2017-09, Vol.72 (9), p.825-831 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

Texto completo disponível

Citações Citado por

Enviar para

Título:
Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial
Autor: Paci, Eugenio ; Puliti, Donella ; Lopes Pegna, Andrea ; Carrozzi, Laura ; Picozzi, Giulia ; Falaschi, Fabio ; Pistelli, Francesco ; Aquilini, Ferruccio ; Ocello, Cristina ; Zappa, Marco ; Carozzi, Francesca M ; Mascalchi, Mario
Assuntos: Aged ; Early Detection of Cancer - methods ; Female ; Follow-Up Studies ; Health risk assessment ; Humans ; Incidence ; Italy - epidemiology ; Kaplan-Meier Estimate ; Lung cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - epidemiology ; Lung Neoplasms - etiology ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Mortality ; Neoplasm Staging ; Registries ; Smoking - adverse effects ; Smoking - epidemiology ; Smoking cessation ; Tomography ; Tomography, X-Ray Computed - methods
É parte de: Thorax, 2017-09, Vol.72 (9), p.825-831
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-News-2
ObjectType-Feature-3
content type line 23
Descrição: BackgroundITALUNG is contributing to the European evaluation of low-dose CT (LDCT) screening for lung cancer (LC).MethodsEligible subjects aged 55–69 years, smokers or ex-smokers (at least 20 pack-years in the last 10 years), were randomised to receive an annual invitation for LDCT screening for 4 years (active group) or to usual care (control group). All participants were followed up for vital status and cause of death (at the end of 2014) and LC incidence (at the end of 2013). Pathological and clinical information was collected from the Tuscan Cancer Registry data.Results1613 subjects were randomly assigned to the active group and 1593 to the control group. At the end of the follow-up period 67 LC cases were diagnosed in the active group and 71 in the control group (rate ratio (RR)=0.93; 95% CI 0.67 to 1.30). A greater proportion of stage I LC was observed in the active group (36% vs 11%, p<0.001). Non-significant reductions of 17% (RR=0.83; 95% CI 0.67 to 1.03) for overall mortality and 30% (RR=0.70; 95% CI 0.47 to 1.03) for LC-specific mortality were estimated.ConclusionsDespite the lack of statistical significance, the ITALUNG trial outcomes suggest that LDCT screening could reduce LC and overall mortality. Moreover, the comparison of the number of LC cases diagnosed in the two groups does not show overdiagnosis after an adequate follow-up period. A pooled analysis of all European screening trials is advocated to assess the benefit-to-harm ratio of LDCT screening and its implementation in public health settings.Trial registration numberResults, NCT02777996.
Editor: England: BMJ Publishing Group LTD
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial

Paci, Eugenio ; Puliti, Donella ; Lopes Pegna, Andrea ; Carrozzi, Laura ; Picozzi, Giulia ; Falaschi, Fabio ; Pistelli, Francesco ; Aquilini, Ferruccio ; Ocello, Cristina ; Zappa, Marco ; Carozzi, Francesca M ; Mascalchi, Mario

England: BMJ Publishing Group LTD

Buscando em bases de dados remotas. Favor aguardar.