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The alternative splicing factor Nova2 regulates vascular development and lumen formation

Giampietro, Costanza ; Deflorian, Gianluca ; Gallo, Stefania ; Di Matteo, Anna ; Pradella, Davide ; Bonomi, Serena ; Belloni, Elisa ; Nyqvist, Daniel ; Quaranta, Valeria ; Confalonieri, Stefano ; Bertalot, Giovanni ; Orsenigo, Fabrizio ; Pisati, Federica ; Ferrero, Elisabetta ; Biamonti, Giuseppe ; Fredrickx, Evelien ; Taveggia, Carla ; Wyatt, Chris D R ; Irimia, Manuel ; Di Fiore, Pier Paolo ; Blencowe, Benjamin J ; Dejana, Elisabetta ; Ghigna, Claudia

Nature communications, 2015-10, Vol.6 (1), p.8479-8479, Article 8479 [Periódico revisado por pares]

England: Nature Publishing Group

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The alternative splicing factor Nova2 regulates vascular development and lumen formation
Autor: Giampietro, Costanza ; Deflorian, Gianluca ; Gallo, Stefania ; Di Matteo, Anna ; Pradella, Davide ; Bonomi, Serena ; Belloni, Elisa ; Nyqvist, Daniel ; Quaranta, Valeria ; Confalonieri, Stefano ; Bertalot, Giovanni ; Orsenigo, Fabrizio ; Pisati, Federica ; Ferrero, Elisabetta ; Biamonti, Giuseppe ; Fredrickx, Evelien ; Taveggia, Carla ; Wyatt, Chris D R ; Irimia, Manuel ; Di Fiore, Pier Paolo ; Blencowe, Benjamin J ; Dejana, Elisabetta ; Ghigna, Claudia
Assuntos: Alternative Splicing - physiology ; Angiogènesi ; Animals ; Antigens, Neoplasm - genetics ; Antigens, Neoplasm - metabolism ; Cells, Cultured ; Endothelial Cells - metabolism ; Endothelium, Vascular - physiology ; Fisiologia ; Medicin och hälsovetenskap ; Mice ; Neovascularization, Physiologic - physiology ; Neuro-Oncological Ventral Antigen ; Neurones ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism
É parte de: Nature communications, 2015-10, Vol.6 (1), p.8479-8479, Article 8479
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work
These authors jointly supervised this work
Descrição: Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular mechanisms underlying this process are poorly understood. Recent studies have shown that neural and vascular systems share common anatomical, functional and molecular similarities. Here we show that the organization of endothelial lumen is controlled at the post-transcriptional level by the alternative splicing (AS) regulator Nova2, which was previously considered to be neural cell-specific. Nova2 is expressed during angiogenesis and its depletion disrupts vascular lumen formation in vivo. Similarly, Nova2 depletion in cultured endothelial cells (ECs) impairs the apical distribution and the downstream signalling of the Par polarity complex, resulting in altered EC polarity, a process required for vascular lumen formation. These defects are linked to AS changes of Nova2 target exons affecting the Par complex and its regulators. Collectively, our results reveal that Nova2 functions as an AS regulator in angiogenesis and is a novel member of the 'angioneurins' family.
Editor: England: Nature Publishing Group
Idioma: Inglês

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The alternative splicing factor Nova2 regulates vascular development and lumen formation

England: Nature Publishing Group

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