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Mitochondria as target of Quantum dots toxicity

Li, Jiahan ; Zhang, Yue ; Xiao, Qi ; Tian, Fangfang ; Liu, Xiaorong ; Li, Ran ; Zhao, Guangyuan ; Jiang, Fenglei ; Liu, Yi

Journal of hazardous materials, 2011-10, Vol.194, p.440-444 [Periódico revisado por pares]

Kidlington: Elsevier B.V

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Título:
Mitochondria as target of Quantum dots toxicity
Autor: Li, Jiahan ; Zhang, Yue ; Xiao, Qi ; Tian, Fangfang ; Liu, Xiaorong ; Li, Ran ; Zhao, Guangyuan ; Jiang, Fenglei ; Liu, Yi
Assuntos: Animals ; Apoptosis ; Applied sciences ; Cadmium tellurides ; Chemical engineering ; energy metabolism ; Exact sciences and technology ; Human ; human health ; lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; liver ; Membrane Lipids - metabolism ; Mitochondria ; Mitochondria, Liver - drug effects ; mitochondrial membrane ; Mitochondrial permeability transition ; Mitochondrial Swelling - drug effects ; Oxygen - metabolism ; permeability ; Pollution ; Quantum Dots ; Rats ; Respiration ; Safety ; Swelling ; Toxicity
É parte de: Journal of hazardous materials, 2011-10, Vol.194, p.440-444
Notas: http://dx.doi.org/10.1016/j.jhazmat.2011.07.113
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SourceType-Scholarly Journals-1
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Descrição: ► The present work investigated the toxicity of CdTe QDs on the function of mitochondria isolated from rat livers. ► These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level. ► QDs toxicity on mitochondria indicates that the QDs require to be further improved before they can be safely used in clinic. Quantum dots (QDs) hold great promise in many biological applications, with the persistence of safety concerns about the environment and human health. The present work investigated the potential toxicity of CdTe QDs on the function of mitochondria isolated from rat livers by examining mitochondrial respiration, swelling, and lipid peroxidation. We observed that QDs can significantly affect the mitochondrial membrane properties, bioenergetics and induce mitochondrial permeability transition (MPT). These results will help us learn more about QDs toxicity at subcellular (mitochondrial) level.
Editor: Kidlington: Elsevier B.V
Idioma: Inglês

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Mitochondria as target of Quantum dots toxicity

Li, Jiahan ; Zhang, Yue ; Xiao, Qi ; Tian, Fangfang ; Liu, Xiaorong ; Li, Ran ; Zhao, Guangyuan ; Jiang, Fenglei ; Liu, Yi

Kidlington: Elsevier B.V

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