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Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

Martens, Eric C ; Neumann, Mareike ; Desai, Mahesh S

Nature reviews. Microbiology, 2018-08, Vol.16 (8), p.457-470 [Periódico revisado por pares]

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Título:
Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Autor: Martens, Eric C ; Neumann, Mareike ; Desai, Mahesh S
Assuntos: Bacteria ; Chronic diseases ; Chronic illnesses ; Epithelial cells ; Health aspects ; Host-bacteria relationships ; Infection ; Infections ; Intestinal mucosa ; Intestine ; Medical examination ; Microorganisms ; Mucosa ; Mucous membrane ; Mucus ; Pathogenic microorganisms ; Small intestine
É parte de: Nature reviews. Microbiology, 2018-08, Vol.16 (8), p.457-470
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: The intestinal mucosal barrier is composed of epithelial cells that are protected by an overlying host-secreted mucous layer and functions as the first line of defence against pathogenic and non-pathogenic microorganisms. Some microorganisms have evolved strategies to either survive in the mucosal barrier or circumvent it to establish infection. In this Review, we discuss the current state of knowledge of the complex interactions of commensal microorganisms with the intestinal mucosal barrier, and we discuss strategies used by pathogenic microorganisms to establish infection by either exploiting different epithelial cell lineages or disrupting the mucous layer, as well as the role of defects in mucus production in chronic disease.
Editor: England: Nature Publishing Group
Idioma: Inglês

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