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Normalized Parameters of Dynamic Contrast-Enhanced Perfusion MRI and DWI-ADC for Differentiation between Posttreatment Changes and Recurrence in Head and Neck Cancer

Baba, A ; Kurokawa, R ; Rawie, E ; Kurokawa, M ; Ota, Y ; Srinivasan, A

American journal of neuroradiology : AJNR, 2022-08, Vol.43 (8), p.1184-1189 [Periódico revisado por pares]

United States: American Society of Neuroradiology

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  • Título:
    Normalized Parameters of Dynamic Contrast-Enhanced Perfusion MRI and DWI-ADC for Differentiation between Posttreatment Changes and Recurrence in Head and Neck Cancer
  • Autor: Baba, A ; Kurokawa, R ; Rawie, E ; Kurokawa, M ; Ota, Y ; Srinivasan, A
  • Assuntos: Contrast Media ; Diffusion Magnetic Resonance Imaging - methods ; Editor's Choice ; Functional ; Head & Neck ; Head and Neck Neoplasms - diagnostic imaging ; Head and Neck Neoplasms - therapy ; Humans ; Magnetic Resonance Imaging - methods ; Perfusion ; Retrospective Studies
  • É parte de: American journal of neuroradiology : AJNR, 2022-08, Vol.43 (8), p.1184-1189
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Differentiating recurrence from benign posttreatment changes has clinical importance in the imaging follow-up of head and neck cancer. This study aimed to investigate the utility of normalized dynamic contrast-enhanced MR imaging and ADC for their differentiation. This study included 51 patients with a history of head and neck cancer who underwent follow-up dynamic contrast-enhanced MR imaging with DWI-ADC, of whom 25 had recurrences and 26 had benign posttreatment changes. Quantitative and semiquantitative dynamic contrast-enhanced MR imaging parameters and ADC of the ROI and reference region were analyzed. Normalized dynamic contrast-enhanced MR imaging parameters and normalized DWI-ADC parameters were calculated by dividing the ROI by the reference region. Normalized plasma volume, volume transfer constant between extravascular extracellular space and blood plasma per minute ( ), area under the curve, and wash-in were significantly higher in patients with recurrence than in those with benign posttreatment change ( = .003 to <.001). The normalized mean ADC was significantly lower in patients with recurrence than in those with benign posttreatment change ( < .001). The area under the receiver operating characteristic curve of the combination of normalized dynamic contrast-enhanced MR imaging parameters with significance (normalized plasma volume, normalized extravascular extracellular space volume per unit tissue volume, normalized , normalized area under the curve, and normalized wash-in) and normalized mean ADC was 0.97 (95% CI, 0.93-1). Normalized dynamic contrast-enhanced MR imaging parameters, normalized mean ADC, and their combination were effective in differentiating recurrence and benign posttreatment changes in head and neck cancer.
  • Editor: United States: American Society of Neuroradiology
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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