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Quasispecies theory and the behavior of RNA viruses

Lauring, Adam S ; Andino, Raul Manchester, Marianne

PLoS pathogens, 2010-07, Vol.6 (7), p.e1001005-e1001005 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Quasispecies theory and the behavior of RNA viruses
Autor: Lauring, Adam S ; Andino, Raul
Manchester, Marianne
Assuntos: Biological Evolution ; Disease ; DNA sequencing ; Drug resistance ; Evolution ; Fitness (Genetics) ; Gene mutations ; Genetic Variation ; Genomes ; Hepatitis C virus ; Human immunodeficiency virus ; Identification and classification ; Influenza ; Methods ; Models, Genetic ; Mutation ; Natural history ; Nucleotide sequencing ; Pathogenesis ; Population ; Population genetics ; Review ; RNA viruses ; RNA Viruses - genetics ; RNA Viruses - physiology ; Theory ; Vaccines ; Viral infections ; Virology/Antivirals, including Modes of Action and Resistance ; Virology/Effects of Virus Infection on Host Gene Expression ; Virology/Emerging Viral Diseases ; Virology/New Therapies, including Antivirals and Immunotherapy ; Virology/Vaccines ; Virology/Virus Evolution and Symbiosis ; Viruses
É parte de: PLoS pathogens, 2010-07, Vol.6 (7), p.e1001005-e1001005
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: A large number of medically important viruses, including HIV, hepatitis C virus, and influenza, have RNA genomes. These viruses replicate with extremely high mutation rates and exhibit significant genetic diversity. This diversity allows a viral population to rapidly adapt to dynamic environments and evolve resistance to vaccines and antiviral drugs. For the last 30 years, quasispecies theory has provided a population-based framework for understanding RNA viral evolution. A quasispecies is a cloud of diverse variants that are genetically linked through mutation, interact cooperatively on a functional level, and collectively contribute to the characteristics of the population. Many predictions of quasispecies theory run counter to traditional views of microbial behavior and evolution and have profound implications for our understanding of viral disease. Here, we discuss basic principles of quasispecies theory and describe its relevance for our understanding of viral fitness, virulence, and antiviral therapeutic strategy.
Editor: United States: Public Library of Science
Idioma: Inglês

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Quasispecies theory and the behavior of RNA viruses

Lauring, Adam S ; Andino, Raul Manchester, Marianne

United States: Public Library of Science

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