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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

Henri, Sandrine ; Poulin, Lionel Franz ; Tamoutounour, Samira ; Ardouin, Laurence ; Guilliams, Martin ; de Bovis, Béatrice ; Devilard, Elisabeth ; Viret, Christophe ; Azukizawa, Hiroaki ; Kissenpfennig, Adrien ; Malissen, Bernard

The Journal of experimental medicine, 2010-01, Vol.207 (1), p.189-206 [Periódico revisado por pares]

United States: Rockefeller University Press

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Título:
CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells
Autor: Henri, Sandrine ; Poulin, Lionel Franz ; Tamoutounour, Samira ; Ardouin, Laurence ; Guilliams, Martin ; de Bovis, Béatrice ; Devilard, Elisabeth ; Viret, Christophe ; Azukizawa, Hiroaki ; Kissenpfennig, Adrien ; Malissen, Bernard
Assuntos: Animals ; Antigen Presentation ; Antigen Presentation - physiology ; Antigens ; Antigens - genetics ; Antigens - immunology ; Antigens, CD ; Antigens, CD - genetics ; Antigens, CD - immunology ; Antigens, Surface ; Antigens, Surface - genetics ; Antigens, Surface - immunology ; Dermis ; Dermis - cytology ; Dermis - immunology ; Female ; Gene Expression Regulation ; Gene Expression Regulation - genetics ; Gene Expression Regulation - immunology ; Gene Expression Regulation - physiology ; Gene Knock-In Techniques ; Histocompatibility Antigens Class II ; Histocompatibility Antigens Class II - genetics ; Histocompatibility Antigens Class II - immunology ; Immunology ; Integrin alpha Chains ; Integrin alpha Chains - genetics ; Integrin alpha Chains - immunology ; Keratinocytes ; Keratinocytes - cytology ; Keratinocytes - immunology ; Langerhans Cells ; Langerhans Cells - cytology ; Langerhans Cells - immunology ; Lectins, C-Type ; Lectins, C-Type - genetics ; Lectins, C-Type - immunology ; Life Sciences ; Lymph Nodes ; Lymph Nodes - cytology ; Lymph Nodes - immunology ; Mannose-Binding Lectins ; Mannose-Binding Lectins - genetics ; Mannose-Binding Lectins - immunology ; Mice ; Mice, Transgenic ; Organ Specificity
É parte de: The Journal of experimental medicine, 2010-01, Vol.207 (1), p.189-206
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC2812532
A. Kissenpfennig’s present address is Centre for Infection and Immunity, School of Medicine, Dentistry and Biomedical Sciences, Queen’s University, Belfast, UK.
S. Henri and L.F. Poulin contributed equally to this paper.
Descrição: Recent studies have challenged the view that Langerhans cells (LCs) constitute the exclusive antigen-presenting cells of the skin and suggest that the dermal dendritic cell (DDC) network is exceedingly complex. Using knockin mice to track and ablate DCs expressing langerin (CD207), we discovered that the dermis contains five distinct DC subsets and identified their migratory counterparts in draining lymph nodes. Based on this refined classification, we demonstrated that the quantitatively minor CD207+ CD103+ DDC subset is endowed with the unique capability of cross-presenting antigens expressed by keratinocytes irrespective of the presence of LCs. We further showed that Y-Ae, an antibody that is widely used to monitor the formation of complexes involving I-Ab molecules and a peptide derived from the I-E alpha chain, recognizes mature skin DCs that express I-Ab molecules in the absence of I-E alpha. Knowledge of this extra reactivity is important because it could be, and already has been, mistakenly interpreted to support the view that antigen transfer can occur between LCs and DDCs. Collectively, these data revisit the transfer of antigen that occurs between keratinocytes and the five distinguishable skin DC subsets and stress the high degree of functional specialization that exists among them.
Editor: United States: Rockefeller University Press
Idioma: Inglês

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CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells

Henri, Sandrine ; Poulin, Lionel Franz ; Tamoutounour, Samira ; Ardouin, Laurence ; Guilliams, Martin ; de Bovis, Béatrice ; Devilard, Elisabeth ; Viret, Christophe ; Azukizawa, Hiroaki ; Kissenpfennig, Adrien ; Malissen, Bernard

United States: Rockefeller University Press

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