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Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis

Graham, Nicola ; Qian, Bin-Zhi

International journal of molecular sciences, 2018-04, Vol.19 (4), p.1121 [Periódico revisado por pares]

Switzerland: MDPI

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  • Título:
    Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis
  • Autor: Graham, Nicola ; Qian, Bin-Zhi
  • Assuntos: Animals ; bone ; Bone Neoplasms - pathology ; Bone Neoplasms - secondary ; cancer-associated fibroblasts ; Cell Proliferation ; dormancy ; Homeostasis ; Humans ; mesenchymal stem cells ; Mesenchymal Stem Cells - physiology ; metastasis ; metastatic niche ; Review ; Stem Cell Niche ; stromal cells ; Tumor Microenvironment
  • É parte de: International journal of molecular sciences, 2018-04, Vol.19 (4), p.1121
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Bone metastasis is the most advanced stage of many cancers and indicates a poor prognosis for patients due to resistance to anti-tumor therapies. The establishment of metastasis within the bone is a multistep process. To ensure survival within the bone marrow, tumor cells must initially colonize a niche in which they can enter dormancy. Subsequently, reactivation permits the proliferation and growth of the tumor cells, giving rise to a macro-metastasis displayed clinically as a bone metastatic lesion. Here, we review the evidences that suggest mesenchymal stromal cells play an important role in each of these steps throughout the development of bone metastasis. Similarities between the molecular mechanisms implicated in these processes and those involved in the homeostasis of the bone indicate that the metastatic cells may exploit the homeostatic processes to their own advantage. Identifying the molecular interactions between the mesenchymal stromal cells and tumor cells that promote tumor development may offer insight into potential therapeutic targets that could be utilized to treat bone metastasis.
  • Editor: Switzerland: MDPI
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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