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Novel InDel variations of the Cry2 gene are associated with litter size in Australian White sheep

Huang, Yangming ; Su, Peng ; Akhatayeva, Zhanerke ; Pan, Chuanying ; Zhang, Qingfeng ; Lan, Xianyong

Theriogenology, 2022-02, Vol.179, p.155-161 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Novel InDel variations of the Cry2 gene are associated with litter size in Australian White sheep
  • Autor: Huang, Yangming ; Su, Peng ; Akhatayeva, Zhanerke ; Pan, Chuanying ; Zhang, Qingfeng ; Lan, Xianyong
  • Assuntos: Animals ; Australia ; Cry2 ; Female ; Genotype ; INDEL Mutation ; Insertion/deletion (InDel) ; Litter size ; Litter Size - genetics ; Marker-assisted selection (MAS) ; Pregnancy ; Sheep ; Sheep - genetics ; Transcription Factors
  • É parte de: Theriogenology, 2022-02, Vol.179, p.155-161
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Cryptochrome 2 (Cry2) gene regulates circadian rhythm and affects reproduction and pregnancy. Therefore, this study aimed to explore polymorphisms of the Cry2 gene and their associations with litter size at different parity in Australian White (AuW) ewes. Five putative insertion or deletion mutations within the Cry2 gene were selected to study their association with litter size. Two novel deletion mutations were identified in intronic region of Cry2 gene and were genotyped by agarose gel electrophoresis and DNA sequencing. The polymorphism information content (PIC) indicated that both mutations were low polymorphism in tested groups. Statistical analysis revealed that the P1-Del-6-bp was significantly correlated with litter size at third parity (P = 0.010), in which individuals with insertion/deletion (ID) genotype had larger litter size than insertion/insertion (II) genotype (P < 0.05). Whereas, the P2-Del-6-bp was significantly correlated with litter size at first parity (P = 0.036), in which individuals with insertion/insertion (II) genotype had larger litter size than insertion/deletion (ID) genotype (P < 0.05). Collectively, these findings may provide new insights to expedite molecular breeding in sheep through marker-assisted selection strategies (MAS). •The presence of InDel mutations in Cry2 was studied in Australian White sheep (n = 602).•These InDel loci P1-Del-6bp and P2-Del-6bp were significantly associated with Australian White sheep litter size.•These findings will provide new insights to expedite molecular breeding in sheep.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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