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Rhino-Orbital-Cerebral Mucormycosis after Allogeneic Hematopoietic Stem Cell Transplantation and Isavuconazole Therapeutic Drug Monitoring during Intestinal Graft versus Host Disease

Andreani, Giacomo ; Fadda, Gianluca ; Gned, Dario ; Dragani, Matteo ; Cavallo, Giovanni ; Monticone, Valentina ; Morotti, Alessandro ; De Gobbi, Marco ; Guerrasio, Angelo ; D'Avolio, Antonio ; Cilloni, Daniela

Mediterranean journal of hematology and infectious diseases, 2019-11, Vol.11 (1), p.e2019061

Università Cattolica del Sacro Cuore

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Título:
Rhino-Orbital-Cerebral Mucormycosis after Allogeneic Hematopoietic Stem Cell Transplantation and Isavuconazole Therapeutic Drug Monitoring during Intestinal Graft versus Host Disease
Autor: Andreani, Giacomo ; Fadda, Gianluca ; Gned, Dario ; Dragani, Matteo ; Cavallo, Giovanni ; Monticone, Valentina ; Morotti, Alessandro ; De Gobbi, Marco ; Guerrasio, Angelo ; D'Avolio, Antonio ; Cilloni, Daniela
Assuntos: Case Report ; Rhino-orbital-cerebral mucormycosis, Isavuconazole, Liposomal amphotericin B, Therapeutic drug monitoring, Deferasirox
É parte de: Mediterranean journal of hematology and infectious diseases, 2019-11, Vol.11 (1), p.e2019061
Descrição: A diagnosis of rhino-orbital-cerebral mucormycosis was made in a 59-year-old man with a secondary acute myeloid leukemia a few days after hematopoietic stem cell transplantation. Prompt treatment with combined antifungal therapy (liposomal amphotericin B and isavuconazole) followed by a procedure of endoscopic sinus surgery resulted in the resolution of the infection. Therapeutic drug monitoring of isavuconazole was performed during the year of treatment showing an increment of plasma concentrations in correspondence with the improvement of intestinal GvHD, thus suggesting that in this or similar conditions TDM for isavuconazole can be of value. A literature review of cases of rhino-orbital-cerebral and rhino-cerebral mucormycosis in allogeneic hematopoietic stem cell transplant recipients was performed.
Editor: Università Cattolica del Sacro Cuore
Idioma: Inglês

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Rhino-Orbital-Cerebral Mucormycosis after Allogeneic Hematopoietic Stem Cell Transplantation and Isavuconazole Therapeutic Drug Monitoring during Intestinal Graft versus Host Disease

Andreani, Giacomo ; Fadda, Gianluca ; Gned, Dario ; Dragani, Matteo ; Cavallo, Giovanni ; Monticone, Valentina ; Morotti, Alessandro ; De Gobbi, Marco ; Guerrasio, Angelo ; D'Avolio, Antonio ; Cilloni, Daniela

Università Cattolica del Sacro Cuore

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