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Clinical Experience of Patients Receiving Doripenem-Containing Regimens for the Treatment of Healthcare-Associated Infections

Chao, Chien-Ming ; Chen, Chi-Chung ; Huang, Hui-Ling ; Chuang, Yin-Ching ; Lai, Chih-Cheng ; Tang, Hung-Jen Zhou, Dongsheng

PloS one, 2016-12, Vol.11 (12), p.e0167522-e0167522 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Clinical Experience of Patients Receiving Doripenem-Containing Regimens for the Treatment of Healthcare-Associated Infections
Autor: Chao, Chien-Ming ; Chen, Chi-Chung ; Huang, Hui-Ling ; Chuang, Yin-Ching ; Lai, Chih-Cheng ; Tang, Hung-Jen
Zhou, Dongsheng
Assuntos: Abdomen ; Adults ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antimicrobial agents ; APACHE ; Bacterial infections ; Biology and Life Sciences ; Carbapenems - therapeutic use ; Care and treatment ; Cross Infection - drug therapy ; Cross Infection - microbiology ; Cross Infection - mortality ; Cross Infection - pathology ; Doripenem ; Dosage and administration ; Drug resistance ; Female ; Health care ; Health services ; Hospital Mortality - trends ; Hospitals ; Humans ; Infection ; Infections ; Intensive care ; Intraabdominal Infections - drug therapy ; Intraabdominal Infections - microbiology ; Intraabdominal Infections - mortality ; Intraabdominal Infections - pathology ; Male ; Medical records ; Medical research ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Nosocomial infections ; Pathogens ; Patients ; People and Places ; Pharmacy ; Pneumonia ; Respiratory tract ; Respiratory tract diseases ; Respiratory Tract Infections - drug therapy ; Respiratory Tract Infections - microbiology ; Respiratory Tract Infections - mortality ; Respiratory Tract Infections - pathology ; Retrospective Studies ; Review boards ; Skin ; Soft Tissue Infections - drug therapy ; Soft Tissue Infections - microbiology ; Soft Tissue Infections - mortality ; Soft Tissue Infections - pathology ; Statistical analysis ; Studies ; Tertiary Care Centers - statistics & numerical data ; Therapy ; Treatment Outcome ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - drug therapy ; Urinary Tract Infections - microbiology ; Urinary Tract Infections - mortality ; Urinary Tract Infections - pathology ; Urogenital system ; Ventilators
É parte de: PloS one, 2016-12, Vol.11 (12), p.e0167522-e0167522
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conceptualization: CMC HJT.Data curation: CCC HLH YCC CCL.Supervision: HJT.Writing – original draft: CMC CCL HJT.
Competing Interests: The authors have declared that no competing interests exist.
Descrição: In this study, we retrospectively reviewed the clinical experience of patients receiving doripenem-containing regimens for the treatment of healthcare-associated infections (HCAIs) in a tertiary care center and assessed the clinical usefulness of doripenem therapy in this clinical setting. In this retrospective study, the medical records of all adult patients who had ever received doripenem-containing therapy for the treatment of HCAIs were reviewed between September 1, 2012 and August 31, 2014, and the following data were extracted: age, gender, type of infection, disease severity, underlying comorbidities or conditions, and laboratory results. Additionally, we also extracted data regarding the rates of mortality and clinical and microbiological response. A total of 184 adult patients with HCAIs who had received doripenem-containing therapy were included in this study. Respiratory tract infections (n = 91, 49.5%) were the most common type of infection, followed by urinary tract infections, intra-abdominal infections and skin and soft tissue infections. The mean APACHE II score was 14.5. The rate of clinical success was 78.2%, and the overall in-hospital mortality rate was only 13.0%. Among patients, in-hospital mortality was independently and significantly associated with APACHE II score (odds ratio (OR), 1.2825; 95% CI, 1.1123-1.4788) and achieving clinical success (OR, 0.003; 95% CI, 0.0003-0.409). In conclusion, the overall in-hospital mortality rate was low and the clinical success rate was high among HCAI patients receiving doripenem treatment. These results suggest that doripenem may be judiciously used for the treatment of patients with HCAIs.
Editor: United States: Public Library of Science
Idioma: Inglês

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Clinical Experience of Patients Receiving Doripenem-Containing Regimens for the Treatment of Healthcare-Associated Infections

Chao, Chien-Ming ; Chen, Chi-Chung ; Huang, Hui-Ling ; Chuang, Yin-Ching ; Lai, Chih-Cheng ; Tang, Hung-Jen Zhou, Dongsheng

United States: Public Library of Science

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