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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Yong, Tuying ; Zhang, Xiaoqiong ; Bie, Nana ; Zhang, Hongbo ; Zhang, Xuting ; Li, Fuying ; Hakeem, Abdul ; Hu, Jun ; Gan, Lu ; Santos, Hélder A ; Yang, Xiangliang

Nature communications, 2019-08, Vol.10 (1), p.3838-16, Article 3838 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy
Autor: Yong, Tuying ; Zhang, Xiaoqiong ; Bie, Nana ; Zhang, Hongbo ; Zhang, Xuting ; Li, Fuying ; Hakeem, Abdul ; Hu, Jun ; Gan, Lu ; Santos, Hélder A ; Yang, Xiangliang
Assuntos: Animals ; Anticancer properties ; Antitumor activity ; Biocompatibility ; Biomimetics ; Blood vessels ; Cancer ; Cell Line, Tumor - cytology ; Cell Line, Tumor - metabolism ; Cell Line, Tumor - transplantation ; Chemotherapy ; Cytotoxicity ; Disease Models, Animal ; Doxorubicin ; Doxorubicin - administration & dosage ; Drug carriers ; Drug Carriers - chemistry ; Drug Compounding - methods ; Drug delivery ; Exocytosis ; Exosomes - chemistry ; Extravasation ; Female ; Humans ; Intravenous administration ; Male ; Metastases ; Mice ; Nanoparticles ; Nanoparticles - chemistry ; Neoplasms - drug therapy ; Neoplasms - pathology ; Neoplastic Stem Cells - drug effects ; Parenchyma ; Porosity ; Porous silicon ; Proof of Concept Study ; Silicon - chemistry ; Spheroids, Cellular - cytology ; Spheroids, Cellular - metabolism ; Spheroids, Cellular - transplantation ; Stem cells ; Toxicity ; Tumor cells ; Tumors ; Xenograft Model Antitumor Assays
É parte de: Nature communications, 2019-08, Vol.10 (1), p.3838-16, Article 3838
Descrição: Developing biomimetic nanoparticles without loss of the integrity of proteins remains a major challenge in cancer chemotherapy. Here, we develop a biocompatible tumor-cell-exocytosed exosome-biomimetic porous silicon nanoparticles (PSiNPs) as drug carrier for targeted cancer chemotherapy. Exosome-sheathed doxorubicin-loaded PSiNPs (DOX@E-PSiNPs), generated by exocytosis of the endocytosed DOX-loaded PSiNPs from tumor cells, exhibit enhanced tumor accumulation, extravasation from blood vessels and penetration into deep tumor parenchyma following intravenous administration. In addition, DOX@E-PSiNPs, regardless of their origin, possess significant cellular uptake and cytotoxicity in both bulk cancer cells and cancer stem cells (CSCs). These properties endow DOX@E-PSiNPs with great in vivo enrichment in total tumor cells and side population cells with features of CSCs, resulting in anticancer activity and CSCs reduction in subcutaneous, orthotopic and metastatic tumor models. These results provide a proof-of-concept for the use of exosome-biomimetic nanoparticles exocytosed from tumor cells as a promising drug carrier for efficient cancer chemotherapy.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

Yong, Tuying ; Zhang, Xiaoqiong ; Bie, Nana ; Zhang, Hongbo ; Zhang, Xuting ; Li, Fuying ; Hakeem, Abdul ; Hu, Jun ; Gan, Lu ; Santos, Hélder A ; Yang, Xiangliang

England: Nature Publishing Group

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