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Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine

Ai Vuen, Lee ; Aun Su-Yin, Evelyn ; Naila Kori, Ahlam ; Shah, T M

BMJ case reports, 2022-03, Vol.15 (3), p.e246922 [Periódico revisado por pares]

England: BMJ Publishing Group LTD

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Título:
Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine
Autor: Ai Vuen, Lee ; Aun Su-Yin, Evelyn ; Naila Kori, Ahlam ; Shah, T M
Assuntos: Anemia ; Antibiotics ; Antigens ; Asia, Southeastern ; Blood platelets ; Blood pressure ; BNT162 Vaccine ; Case Reports: Unusual association of diseases/symptoms ; Cognitive ability ; Coronaviruses ; COVID-19 - prevention & control ; COVID-19 vaccines ; COVID-19 Vaccines - adverse effects ; Creatinine ; Disease ; Factor VIII - therapeutic use ; Family medical history ; Hemoglobin ; Hemophilia ; Hemophilia A - diagnosis ; Hemophilia A - drug therapy ; Hemophilia A - etiology ; Humans ; Infections ; Iron ; Laboratories ; Male ; Mortality ; Purpura ; SARS-CoV-2 ; Steroids ; Ultrasonic imaging
É parte de: BMJ case reports, 2022-03, Vol.15 (3), p.e246922
Notas: ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
ObjectType-Article-3
Descrição: Acquired haemophilia A (AHA) is a rare bleeding disorder with high morbidity and mortality, but it is eminently treatable if diagnosis and treatment are prompt. We report a case of AHA in Southeast Asia following the administration of the Pfizer-BioNTech COVID-19 vaccine. A man in his 80s developed multiple bruises 2 weeks after his first dose of the COVID-19 vaccine. Diagnosis was delayed due to his cognitive impairment and low clinical suspicion. This led to a representation with worsening ecchymosis, a left thigh haematoma and symptomatic anaemia. Laboratory testing was notable for an isolated prolongation of the activated partial thromboplastin time, which remained uncorrected in the mixing test. Further testing confirmed the presence of factor VIII (FVIII) inhibitors and low FVIII titres of 6.7%. He responded to treatment with intravenous methylprednisolone and recombinant activated FVII. Screening for autoimmune diseases and malignancies was negative.
Editor: England: BMJ Publishing Group LTD
Idioma: Inglês

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Case of acquired haemophilia a in Southeast Asia following COVID-19 vaccine

Ai Vuen, Lee ; Aun Su-Yin, Evelyn ; Naila Kori, Ahlam ; Shah, T M

England: BMJ Publishing Group LTD

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