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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

Li, Ting ; van Rooij, Daan ; Mota, Nina Roth ; Buitelaar, Jan K ; Ambrosino, Sara ; Banaschewski, Tobias ; Bandeira, Cibele E ; Bau, Claiton HD ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A ; Biederman, Joseph ; Bralten, Janita ; Bramati, Ivanei E ; Brandeis, Daniel ; Berm, Silvia ; Busatto, Geraldo F ; Calvo, Anna ; Castellanos, Francisco X ; Cercignani, Mara ; Chantiluke, Kaylita C ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cubillo, Ana I ; Cupertino, Renata B ; de Zeeuw, Parick ; Durston, Sarah ; Earl, Eric A ; Epstein, Jeffery N ; Ethofer, Thomas ; Fallgatter, Andreas J ; Fair, Damien A ; Faraone, Stephen V ; Frodl, Thomas ; Gabel, Matt C ; Gogberashvili, Tinatin ; Grevet, Eugenio H ; Haavik, Jan ; Harrison, Neil A ; Hartman, Catharina A ; Heslenfeld, Dirk J ; Hoekstra, Pieter J ; Høvik, Marie F ; Jahanshad, Neda ; Kardatzki, Bernd ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R ; Lundervold, Astri J ; Malpas, Charles B ; Mattos, Paulo ; McCarthy, Hazel ; Nicolau, Rosa ; Nigg, Joel T ; Tuura, Ruth L O'Gorman ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Picon, Felipe A ; Plessen, Kerstin J ; Ramos‐Quiroga, J Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro GP ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne JS ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J ; Skokauskas, Norbert ; Vila, Juan Carlos Soliva ; Soloveva, Anastasiia ; Stevens, Michael C ; Sudre, Gustavo ; Tamm, Leanne ; Thompson, Paul M ; Tovar‐Moll, Fernanda ; van Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; von Polier, Georg G ; Walitza, Susanne ; Yoncheva, Yuliya N ; Zanetti, Marcus V ; Ziegler, Georg C ; Anikin, Anatoly ; Asherson, Philip ; Baranov, Alexandr ; Chaim‐Avanicini, Tiffany ; Dale, Anders M

Journal of Child Psychology and Psychiatry, 2021-09, Vol.62 (9), p.1140-1149

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Título:
Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes
Autor: Li, Ting ; van Rooij, Daan ; Mota, Nina Roth ; Buitelaar, Jan K ; Ambrosino, Sara ; Banaschewski, Tobias ; Bandeira, Cibele E ; Bau, Claiton HD ; Baumeister, Sarah ; Baur‐Streubel, Ramona ; Bellgrove, Mark A ; Biederman, Joseph ; Bralten, Janita ; Bramati, Ivanei E ; Brandeis, Daniel ; Berm, Silvia ; Busatto, Geraldo F ; Calvo, Anna ; Castellanos, Francisco X ; Cercignani, Mara ; Chantiluke, Kaylita C ; Christakou, Anastasia ; Coghill, David ; Conzelmann, Annette ; Cubillo, Ana I ; Cupertino, Renata B ; de Zeeuw, Parick ; Durston, Sarah ; Earl, Eric A ; Epstein, Jeffery N ; Ethofer, Thomas ; Fallgatter, Andreas J ; Fair, Damien A ; Faraone, Stephen V ; Frodl, Thomas ; Gabel, Matt C ; Gogberashvili, Tinatin ; Grevet, Eugenio H ; Haavik, Jan ; Harrison, Neil A ; Hartman, Catharina A ; Heslenfeld, Dirk J ; Hoekstra, Pieter J ; Høvik, Marie F ; Jahanshad, Neda ; Kardatzki, Bernd ; Karkashadze, Georgii ; Kelly, Clare ; Kohls, Gregor ; Konrad, Kerstin ; Kuntsi, Jonna ; Lazaro, Luisa ; Lera‐Miguel, Sara ; Lesch, Klaus‐Peter ; Louza, Mario R ; Lundervold, Astri J ; Malpas, Charles B ; Mattos, Paulo ; McCarthy, Hazel ; Nicolau, Rosa ; Nigg, Joel T ; Tuura, Ruth L O'Gorman ; Oosterlaan, Jaap ; Oranje, Bob ; Paloyelis, Yannis ; Pauli, Paul ; Picon, Felipe A ; Plessen, Kerstin J ; Ramos‐Quiroga, J Antoni ; Reif, Andreas ; Reneman, Liesbeth ; Rosa, Pedro GP ; Rubia, Katya ; Schrantee, Anouk ; Schweren, Lizanne JS ; Seitz, Jochen ; Shaw, Philip ; Silk, Tim J ; Skokauskas, Norbert ; Vila, Juan Carlos Soliva ; Soloveva, Anastasiia ; Stevens, Michael C ; Sudre, Gustavo ; Tamm, Leanne ; Thompson, Paul M ; Tovar‐Moll, Fernanda ; van Erp, Theo GM ; Vance, Alasdair ; Vilarroya, Oscar ; Vives‐Gilabert, Yolanda ; von Polier, Georg G ; Walitza, Susanne ; Yoncheva, Yuliya N ; Zanetti, Marcus V ; Ziegler, Georg C ; Anikin, Anatoly ; Asherson, Philip ; Baranov, Alexandr ; Chaim‐Avanicini, Tiffany ; Dale, Anders M
Assuntos: ADHD ; Adult ; Applied and developmental psychology ; Attention Deficit Disorder with Hyperactivity ; Attention Deficit Hyperactivity Disorder (ADHD) ; Biological Psychology ; Brain ; Brain Disorders ; Case-Control Studies ; Clinical and health psychology ; Clinical Research ; Clinical Sciences ; Cognitive Sciences ; community detection ; Developmental & Child Psychology ; effect sizes ; ENIGMA ADHD Working Group ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Mental Health ; neuroanatomic heterogeneity ; Neurosciences ; Pediatric ; Psychology ; subcortical volume ; Thalamus
É parte de: Journal of Child Psychology and Psychiatry, 2021-09, Vol.62 (9), p.1140-1149
Notas: 1140 - 1149
Journal of Child Psychology and Psychiatry, vol 62, iss 9
Descrição: BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes.MethodsUsing the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks.ResultsExploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men.ConclusionsOur results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups.
Editor: eScholarship, University of California
Idioma: Inglês

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Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes

eScholarship, University of California

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