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Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas

CHATTERJEE, S ; WILLIS, N ; LOCKS, S. M ; MOTT, J. H ; KELLY, C. G

British journal of radiology, 2011-12, Vol.84 (1008), p.1083-1090 [Periódico revisado por pares]

London: British Institute of Radiology

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Título:
Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas
Autor: CHATTERJEE, S ; WILLIS, N ; LOCKS, S. M ; MOTT, J. H ; KELLY, C. G
Assuntos: Algorithms ; Applied radiobiology (equipment, dosimetry...) ; Biological and medical sciences ; Biological effects of radiation ; Carcinoma, Squamous Cell - radiotherapy ; Dose-Response Relationship, Radiation ; Female ; Fundamental and applied biological sciences. Psychology ; Head and Neck Neoplasms - radiotherapy ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Radiobiology ; Radiometry ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Conformal - methods ; Radiotherapy, Intensity-Modulated - methods ; Tissues, organs and organisms biophysics ; Tomography, Spiral Computed - methods ; Tumors
É parte de: British journal of radiology, 2011-12, Vol.84 (1008), p.1083-1090
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: The usual radical radiotherapy treatment prescribed for head and neck squamous cell carcinoma (HNSCC) is 70 Gy (in 2 Gy per fraction equivalent) administered to the high-risk target volume (TV). This can be planned using either a forward-planned photon-electron junction technique (2P) or a single-phase (1P) forward-planned technique developed in-house. Alternatively, intensity-modulated radiotherapy (IMRT) techniques, including helical tomotherapy (HT), allow image-guided inversely planned treatments. This study was designed to compare these three planning techniques with regards to TV coverage and the dose received by organs at risk. We compared the dose-volume histograms and conformity indices (CI) of the three planning processes in five patients with HNSCC. The tumour control probability (TCP), normal tissue complication probability (NTCP) and uncomplicated tumour control probability (UCP) were calculated for each of the 15 plans. In addition, we explored the radiobiological rationality of a dose-escalation strategy. The CI for the high-risk clinical TV (CTV1) in the 5 patients were 0.78, 0.76, 0.82, 0.72 and 0.81 when HT was used; 0.58, 0.56, 0.47, 0.35 and 0.60 for the single-phase forward-planned technique and 0.46, 0.36, 0.29, 0.22 and 0.49 for the two-phase technique. The TCP for CTV1 with HT were 79.2%, 85.2%, 81.1%, 83.0% and 53.0%; for single-phase forward-planned technique, 76.5%, 86.9%, 73.4%, 81.8% and 31.8% and for the two-phase technique, 38.2%, 86.2%, 42.7%, 0.0% and 3.4%. Dose escalation using HT confirmed the radiobiological advantage in terms of TCP. TCP for the single-phase plans was comparable to that of HT plans, whereas that for the two-phase technique was lower. Centres that cannot provide IMRT for the radical treatment of all patients could implement the single-phase technique as standard to attain comparable TCP. However, IMRT produced better UCP, thereby enabling the exploration of dose escalation.
Editor: London: British Institute of Radiology
Idioma: Inglês

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Dosimetric and radiobiological comparison of helical tomotherapy, forward-planned intensity-modulated radiotherapy and two-phase conformal plans for radical radiotherapy treatment of head and neck squamous cell carcinomas

CHATTERJEE, S ; WILLIS, N ; LOCKS, S. M ; MOTT, J. H ; KELLY, C. G

London: British Institute of Radiology

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