Idioma:

Amphiphysin autoimmunity: Paraneoplastic accompaniments

Pittock, Sean J. ; Lucchinetti, Claudia F. ; Parisi, Joseph E. ; Benarroch, Eduardo E. ; Mokri, Bahram ; Stephan, Christina L. ; Kim, Kwang-Kuk ; Kilimann, Manfred W. ; Lennon, Vanda A.

Annals of neurology, 2005-07, Vol.58 (1), p.96-107 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Texto completo disponível

Citações Citado por

Enviar para

Título:
Amphiphysin autoimmunity: Paraneoplastic accompaniments
Autor: Pittock, Sean J. ; Lucchinetti, Claudia F. ; Parisi, Joseph E. ; Benarroch, Eduardo E. ; Mokri, Bahram ; Stephan, Christina L. ; Kim, Kwang-Kuk ; Kilimann, Manfred W. ; Lennon, Vanda A.
Assuntos: Aged ; Aged, 80 and over ; Animals ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Brain - immunology ; Brain - pathology ; Female ; Ganglia, Spinal - immunology ; Ganglia, Spinal - pathology ; Humans ; Immunoglobulin G - blood ; Magnetic Resonance Imaging ; Male ; Medical sciences ; MEDICIN ; MEDICINE ; Mice ; Middle Aged ; Neoplasms - complications ; Nerve Tissue Proteins - immunology ; Neurology ; Paraneoplastic Syndromes - epidemiology ; Paraneoplastic Syndromes - etiology ; Paraneoplastic Syndromes - physiopathology ; Pneumology ; Spinal Cord - immunology ; Spinal Cord - pathology ; Stiff-Person Syndrome - epidemiology ; Stiff-Person Syndrome - physiopathology ; T-Lymphocytes - immunology ; Tumors of the nervous system. Phacomatoses ; Tumors of the respiratory system and mediastinum
É parte de: Annals of neurology, 2005-07, Vol.58 (1), p.96-107
Notas: ArticleID:ANA20529
ark:/67375/WNG-NSKFWZJJ-Q
istex:FBE393B2ECE454F6F82238BBF551AEC9B33885AD
ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Descrição: Amphiphysin‐IgG was identified in 71 patients among 120,000 evaluated serologically for paraneoplastic autoantibodies. Clinical information was available for 63 patients. Cancer was detected in 50 (mostly limited), proven histologically in 46, and was imaged intrathoracically in 4 patients (lung, small–cell [27] and non–small cell [1]), breast [16] and melanoma [2]). Neurological accompaniments included (decreasing frequency): neuropathy, encephalopathy, myelopathy, stiff‐man phenomena, and cerebellar syndrome. In a case examined neuropathologically, parenchymal T‐lymphocyte infiltration (predominantly CD8+) was prominent in lower brainstem, spinal cord, and dorsal root ganglion. Coexisting paraneoplastic autoantibodies, identified in 74% of patients, predicted a common neoplasm and indicated other neuronal autoantigen targets that plausibly explained several neurological manifestations; for example, P/Q‐type Ca2+‐channel antibody with Lambert–Eaton syndrome (n = 5), anti‐neuronal nuclear antibody type 1 with sensory neuronopathy (n = 7), K+‐channel antibody with limbic encephalitis (n = 1) or neuromyotonia (n = 1), and collapsin response‐mediator protein‐5‐IgG with optic neuritis (n = 3). Patients with isolated amphiphysin‐IgG (n = 19) were more likely to be women (with breast cancer, p < 0.05) and to have myelopathy or stiff‐man phenomena (p < 0.01). Overall, a minority of women (39%) and men (12%) had stiff‐man phenomena. Only 10% of women (some with lung carcinoma) and 4% of men fulfilled diagnostic criteria for stiff‐man syndrome. Ann Neurol 2005;58:96–107
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Amphiphysin autoimmunity: Paraneoplastic accompaniments

Pittock, Sean J. ; Lucchinetti, Claudia F. ; Parisi, Joseph E. ; Benarroch, Eduardo E. ; Mokri, Bahram ; Stephan, Christina L. ; Kim, Kwang-Kuk ; Kilimann, Manfred W. ; Lennon, Vanda A.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Buscando em bases de dados remotas. Favor aguardar.