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Gel Dosimetry Analysis of Gold Nanoparticle Application in Kilovoltage Radiation Therapy

Marques, T ; Schwarcke, M ; Garrido, C ; Zucolot, V ; Baffa, O ; Nicolucci, P

Journal of physics. Conference series, 2010-11, Vol.250 (1), p.012084 [Periódico revisado por pares]

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Título:
Gel Dosimetry Analysis of Gold Nanoparticle Application in Kilovoltage Radiation Therapy
Autor: Marques, T ; Schwarcke, M ; Garrido, C ; Zucolot, V ; Baffa, O ; Nicolucci, P
Assuntos: Dosimeters ; Dosimetry ; Gold ; Nanoparticles ; Polymer gels ; Radiation therapy
É parte de: Journal of physics. Conference series, 2010-11, Vol.250 (1), p.012084
Descrição: In this work gold nanoparticles (AuNP) were embedded in MAGIC-f gel and irradiated in a 250 kV x-ray clinical beam. The signal of non-irradiated gel samples containing AuNPs showed maximum difference of 0.5% related to gel without nanoparticles. Different AuNPs concentrations were studied: 0.10 mM, 0.05 mM and 0.02 mM, presenting dose enhancements of 106%, 90% and 77% respectively. Monte Carlo spectrometry was performed to quantify theoretical changes in photon energy spectrums due to AuNPs presence. Concordance between simulated dose enhancements and gel dosimetry measurements was better than 97% to all concentrations studied. This study evidences that polymer gel dosimetry as a suitable tool to perform dosimetric investigations of nanoparticle applications in Radiation Therapy.
Editor: Bristol: IOP Publishing
Idioma: Inglês

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