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On the whereabouts of SARS-CoV-2 in the human body: A systematic review

Trypsteen, Wim ; Van Cleemput, Jolien ; Snippenberg, Willem van ; Gerlo, Sarah ; Vandekerckhove, Linos Wilen, Craig B.

PLoS pathogens, 2020-10, Vol.16 (10), p.e1009037-e1009037 [Periódico revisado por pares]

United States: Public Library of Science

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On the whereabouts of SARS-CoV-2 in the human body: A systematic review
Autor: Trypsteen, Wim ; Van Cleemput, Jolien ; Snippenberg, Willem van ; Gerlo, Sarah ; Vandekerckhove, Linos
Wilen, Craig B.
Assuntos: ACE2 ; Angiotensin-converting enzyme 2 ; Antiviral Agents - pharmacology ; Betacoronavirus - drug effects ; Betacoronavirus - pathogenicity ; Biology and life sciences ; Blood vessels ; Body fluids ; Breast milk ; Care and treatment ; Cerebrospinal fluid ; China ; Containment ; Control ; Coronavirus Infections - drug therapy ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Development and progression ; Disease transmission ; Epidemics ; Esophagus ; Female ; Health aspects ; Host-virus relationships ; Human body ; Human populations ; Human tissues ; Humans ; Internal medicine ; Intestine ; Lung - metabolism ; Lung - virology ; Lungs ; Male ; Medical research ; Medicine ; Medicine and health sciences ; Microscopy ; Milk ; Mucus ; Organotropism ; Organs ; Pandemics ; Pathogenesis ; Pediatrics ; Peptidyl-Dipeptidase A - drug effects ; Peptidyl-Dipeptidase A - metabolism ; Pharynx ; Pneumonia, Viral - drug therapy ; Pneumonia, Viral - virology ; Receptors ; Receptors, Virus - drug effects ; Receptors, Virus - metabolism ; Reproductive organs ; Ribonucleic acid ; RNA ; Saliva ; SARS-CoV-2 ; Semen ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Social Sciences ; Supervision ; Systematic review ; Trachea ; Viral diseases ; Virus research ; Viruses
É parte de: PLoS pathogens, 2020-10, Vol.16 (10), p.e1009037-e1009037
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The authors have declared that no competing interests exist.
Descrição: Since SARS-CoV-2 appeared in the human population, the scientific community has scrambled to gather as much information as possible to find good strategies for the containment and treatment of this pandemic virus. Here, we performed a systematic review of the current (pre)published SARS-CoV-2 literature with a focus on the evidence concerning SARS-CoV-2 distribution in human tissues and viral shedding in body fluids. In addition, this evidence is aligned with published ACE2 entry-receptor (single cell) expression data across the human body to construct a viral distribution and ACE2 receptor body map. We highlight the broad organotropism of SARS-CoV-2, as many studies identified viral components (RNA, proteins) in multiple organs, including the pharynx, trachea, lungs, blood, heart, vessels, intestines, brain, male genitals and kidneys. This also implicates the presence of viral components in various body fluids such as mucus, saliva, urine, cerebrospinal fluid, semen and breast milk. The main SARS-CoV-2 entry receptor, ACE2, is expressed at different levels in multiple tissues throughout the human body, but its expression levels do not always correspond with SARS-CoV-2 detection, indicating that there is a complex interplay between virus and host. Together, these data shed new light on the current view of SARS-CoV-2 pathogenesis and lay the foundation for better diagnosis and treatment of COVID-19 patients.
Editor: United States: Public Library of Science
Idioma: Inglês

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On the whereabouts of SARS-CoV-2 in the human body: A systematic review

Trypsteen, Wim ; Van Cleemput, Jolien ; Snippenberg, Willem van ; Gerlo, Sarah ; Vandekerckhove, Linos Wilen, Craig B.

United States: Public Library of Science

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