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Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes

Ma, Yilong ; Tang, Chengke ; Chaly, Thomas ; Greene, Paul ; Breeze, Robert ; Fahn, Stanley ; Freed, Curt ; Dhawan, Vijay ; Eidelberg, David

The Journal of nuclear medicine (1978), 2009-12, Vol.51 (1), p.7-15 [Periódico revisado por pares]

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Título:
Dopamine Cell Implantation in Parkinson's Disease: Long-Term Clinical and 18F-FDOPA PET Outcomes
Autor: Ma, Yilong ; Tang, Chengke ; Chaly, Thomas ; Greene, Paul ; Breeze, Robert ; Fahn, Stanley ; Freed, Curt ; Dhawan, Vijay ; Eidelberg, David
É parte de: The Journal of nuclear medicine (1978), 2009-12, Vol.51 (1), p.7-15
Descrição: We have previously reported the results of a 1-y double-blind, placebo-controlled study of embryonic dopamine cell implantation for Parkinson’s disease. At the end of the blinded phase, we found a significant increase in putamen uptake on 18 F-fluorodopa ( 18 F-FDOPA) PET reflecting the viability of the grafts. Nonetheless, clinical improvement was significant only in younger (age ≤ 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson’s Disease Rating Scale (UPDRS) motor scores.
Editor: Soc Nuclear Med
Idioma: Inglês

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