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New cardiovascular risk determinants do exist and are clinically useful

Smulders, Yvo M. ; Thijs, Abel ; Twisk, Jos W.

European heart journal, 2008-02, Vol.29 (4), p.436-440 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
New cardiovascular risk determinants do exist and are clinically useful
Autor: Smulders, Yvo M. ; Thijs, Abel ; Twisk, Jos W.
Assuntos: Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Epidemiologic Methods ; Epidemiology ; Humans ; Medical sciences ; Risk estimation ; Risk factors
É parte de: European heart journal, 2008-02, Vol.29 (4), p.436-440
Notas: istex:3FED859880F316F42500F5C2C29F6B97C4287F77
Related-article-href:10.1093/eurheartj/ehm644
related-article-ID:RA1
ArticleID:ehm566
ark:/67375/HXZ-L089QJHJ-Z
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
Descrição: Can we improve our understanding of cardiovascular disease (CVD) causality and prediction? Intuitively, we can. Recent publications, however, could be misinterpreted as suggesting the opposite. First, the Interheart study, which concluded that nine conventional risk factors explain >90% of premature myocardial infarction, is at risk for being interpreted as saying that other, ‘new’ cardiovascular risk factors can only cause a small remaining fraction of disease of at most 10%. Secondly, papers addressing the predictive value of new risk factors or markers of early CVD risk have concluded that risk prediction does not improve by adding these variables to risk models. In this paper, we will explain that searching for ‘new causes’ of CVD is still highly relevant, and that improvement of risk prediction is often assessed using inappropriate statistical methodology.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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New cardiovascular risk determinants do exist and are clinically useful

Smulders, Yvo M. ; Thijs, Abel ; Twisk, Jos W.

Oxford: Oxford University Press

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