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Transition-metal-free catalytic hydroboration reduction of amides to amines

Yao, Wubing ; Wang, Jiali ; Zhong, Aiguo ; Wang, Shiliang ; Shao, Yinlin

Organic Chemistry Frontiers, 2020-11, Vol.7 (21), p.3515-3520 [Periódico revisado por pares]

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Título:
Transition-metal-free catalytic hydroboration reduction of amides to amines
Autor: Yao, Wubing ; Wang, Jiali ; Zhong, Aiguo ; Wang, Shiliang ; Shao, Yinlin
Assuntos: Amides ; Amines ; Catalysts ; Chemical reduction ; Chemical synthesis ; Deoxygenation ; Hydroboration ; Reduction (metal working) ; Selective catalytic reduction ; Transition metals
É parte de: Organic Chemistry Frontiers, 2020-11, Vol.7 (21), p.3515-3520
Descrição: The selective catalytic reduction of amides to value-added amine products is a desirable but challenging transformation. Here, we present a combined KO t Bu/BEt 3 catalyst for the deoxygenative reduction of tertiary, secondary, and even notoriously challenging primary carboxamides with pinacolborane (HBpin) at 25–60 °C. This novel transition-metal-free methodology is readily applicable to the synthesis of drug molecules.
Editor: London: Royal Society of Chemistry
Idioma: Inglês

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