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Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers

Ding, Jun ; Ding, Zhengang ; Yuan, Fang ; Guo, Jianyi ; Chen, Hao ; Gao, Wenwei ; Wang, Ren ; Gu, Yi ; Chen, Jiong ; Guo, Yan ; Tian, Hengli

Arquivos de neuro-psiquiatria, 2015-04, Vol.73 (4), p.342-349 [Periódico revisado por pares]

Brazil: Academia Brasileira de Neurologia - ABNEURO

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Título:
Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers
Autor: Ding, Jun ; Ding, Zhengang ; Yuan, Fang ; Guo, Jianyi ; Chen, Hao ; Gao, Wenwei ; Wang, Ren ; Gu, Yi ; Chen, Jiong ; Guo, Yan ; Tian, Hengli
Assuntos: Animals ; biomarcadores ; Biomarkers - analysis ; Brain Chemistry ; Brain Injuries - diagnosis ; Brain Injuries - metabolism ; Cerebral Cortex - chemistry ; Disease Models, Animal ; Electrophoresis, Gel, Two-Dimensional ; eletroforese bidimensional em gel ; espectrometria de massa ; lesão traumática cerebral ; Male ; Mass Spectrometry ; NEUROSCIENCES ; Prognosis ; Proteomics ; proteômica ; PSYCHIATRY ; Random Allocation ; Rats, Sprague-Dawley ; Reference Values ; Time Factors
É parte de: Arquivos de neuro-psiquiatria, 2015-04, Vol.73 (4), p.342-349
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Many studies of protein expression after traumatic brain injury (TBI) have identified biomarkers for diagnosing or determining the prognosis of TBI. In this study, we searched for additional protein markers of TBI using a fluid perfusion impact device to model TBI in S-D rats. Two-dimensional gel electrophoresis and mass spectrometry were used to identify differentially expressed proteins. After proteomic analysis, we detected 405 and 371 protein spots within a pH range of 3-10 from sham-treated and contused brain cortex, respectively. Eighty protein spots were differentially expressed in the two groups and 20 of these proteins were identified. This study validated the established biomarkers of TBI and identified potential biomarkers that could be examined in future work.
Editor: Brazil: Academia Brasileira de Neurologia - ABNEURO
Idioma: Inglês;Português

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Proteomics analysis after traumatic brain injury in rats: the search for potential biomarkers

Ding, Jun ; Ding, Zhengang ; Yuan, Fang ; Guo, Jianyi ; Chen, Hao ; Gao, Wenwei ; Wang, Ren ; Gu, Yi ; Chen, Jiong ; Guo, Yan ; Tian, Hengli

Brazil: Academia Brasileira de Neurologia - ABNEURO

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