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Sagittal Abdominal Diameter as a Surrogate Marker of Insulin Resistance in an Admixtured Population--Brazilian Metabolic Syndrome Study (BRAMS)

Vasques, Ana Carolina J ; Cassani, Roberta S L ; Forti, Adriana C e ; Vilela, Brunna S ; Pareja, José Carlos ; Tambascia, Marcos Antonio ; Geloneze, Bruno Sanchez-Margalet, Victor

PloS one, 2015-05, Vol.10 (5), p.e0125365-e0125365 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Sagittal Abdominal Diameter as a Surrogate Marker of Insulin Resistance in an Admixtured Population--Brazilian Metabolic Syndrome Study (BRAMS)
Autor: Vasques, Ana Carolina J ; Cassani, Roberta S L ; Forti, Adriana C e ; Vilela, Brunna S ; Pareja, José Carlos ; Tambascia, Marcos Antonio ; Geloneze, Bruno
Sanchez-Margalet, Victor
Assuntos: Abdomen ; Adult ; Anthropometry ; Biomarkers ; Body fat ; Body mass ; Body measurements ; Body weight ; Brazil ; Cardiovascular disease ; Comparative analysis ; Complications and side effects ; Correlation analysis ; Diabetes mellitus ; Diagnosis ; Female ; Glucose ; Health risk assessment ; Health risks ; Hip ; Humans ; Insulin ; Insulin Resistance ; Metabolic disorders ; Metabolic syndrome ; Metabolic Syndrome - diagnosis ; Metabolic Syndrome - ethnology ; Metabolic syndrome X ; Middle Aged ; Minority & ethnic groups ; Obesity ; Overweight ; Physiological aspects ; Population studies ; Risk factors ; ROC Curve ; Sagittal Abdominal Diameter ; Statistical analysis ; Studies ; Young Adult
É parte de: PloS one, 2015-05, Vol.10 (5), p.e0125365-e0125365
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
These authors also contributed equally to this work.
Membership of the BRAMS investigators is listed in the Acknowledgments.
Conceived and designed the experiments: ACJV JCP MAT BG. Performed the experiments: ACJV RSLC ACF BSV BG BI. Analyzed the data: ACJV BG. Contributed reagents/materials/analysis tools: ACJV JCP MAT BG. Wrote the paper: ACJV BG.
Descrição: Sagittal abdominal diameter (SAD) has been proposed as a surrogate marker of insulin resistance (IR). However, the utilization of SAD requires specific validation for each ethnicity. We aimed to investigate the potential use of SAD, compared with classical anthropometrical parameters, as a surrogate marker of IR and to establish the cutoff values of SAD for screening for IR. A multicenter population survey on metabolic disorders was conducted. A race-admixtured sample of 824 adult women was assessed. The anthropometric parameters included: BMI, waist circumference (WC), waist-to-hip ratio and SAD. IR was determined by a hyperglycemic clamp and the HOMA-IR index. After adjustments for age and total body fat mass, SAD (r = 0.23 and r = -0.70) and BMI (r = 0.20 and r = -0.71) were strongly correlated with the IR measured by the HOMA-IR index and the clamp, respectively (p < 0.001). In the ROC analysis, the optimal cutoff for SAD in women was 21.0 cm. The women with an increased SAD presented 3.2 (CI 95%: 2.1-5.0) more likelihood of having IR, assessed by the HOMA-IR index compared with those with normal SAD (p < 0.001); whereas women with elevated BMI and WC were 2.1 (95% CI: 1.4-3.3) and 2.8 (95% CI: 1.7-4.5) more likely to have IR (p < 0.001), respectively. No statistically significant results were found for waist-to-hip ratio. SAD can be a suitable surrogate marker of IR. Understanding and applying routine and simplified methods is essential because IR is associated with an increased risk of obesity-related diseases even in the presence of normal weight, slight overweight, as well as in obesity. Further prospective analysis will need to verify SAD as a determinant of clinical outcomes, such as type 2 diabetes and cardiovascular events, in the Brazilian population.
Editor: United States: Public Library of Science
Idioma: Inglês

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Sagittal Abdominal Diameter as a Surrogate Marker of Insulin Resistance in an Admixtured Population--Brazilian Metabolic Syndrome Study (BRAMS)

Vasques, Ana Carolina J ; Cassani, Roberta S L ; Forti, Adriana C e ; Vilela, Brunna S ; Pareja, José Carlos ; Tambascia, Marcos Antonio ; Geloneze, Bruno Sanchez-Margalet, Victor

United States: Public Library of Science

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