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The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry

Kara-José, Andrea C ; Melo, Jr, Luiz Alberto S ; Esporcatte, Bruno L B ; Endo, Angelica T N H ; Leite, Mauro Toledo ; Tavares, Ivan Maynart Acott, Ted S.

PloS one, 2017-07, Vol.12 (7), p.e0181428-e0181428 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry
Autor: Kara-José, Andrea C ; Melo, Jr, Luiz Alberto S ; Esporcatte, Bruno L B ; Endo, Angelica T N H ; Leite, Mauro Toledo ; Tavares, Ivan Maynart
Acott, Ted S.
Assuntos: Accuracy ; Aged ; Area Under Curve ; Biology and Life Sciences ; Cataracts ; Correlation ; Cross sections ; Cross-Sectional Studies ; Diagnosis ; Diagnostic systems ; Engineering and Technology ; Eye (anatomy) ; Female ; Glaucoma ; Glaucoma, Open-Angle - diagnosis ; Horizontal cells ; Humans ; Lasers ; Male ; Medical imaging ; Medicine and Health Sciences ; Methods ; Middle Aged ; Nuclear factor I ; Optic Disk - diagnostic imaging ; Optic Disk - pathology ; Optic nerve ; Optical Coherence Tomography ; Optical tomography ; Optics ; Patient outcomes ; Patients ; Polarimetry ; Prognosis ; Research and Analysis Methods ; Retina ; Retinal ganglion cells ; ROC Curve ; SAP protein ; Scanning ; Scanning Laser Polarimetry ; Severity of Illness Index ; Structural damage ; Structure-function relationships ; Surgery ; Tomography, Optical Coherence ; Visual Field Tests
É parte de: PloS one, 2017-07, Vol.12 (7), p.e0181428-e0181428
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Undefined-1
ObjectType-Feature-3
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Competing Interests: The authors have declared that no competing interests exist.
Descrição: Our objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario.
Editor: United States: Public Library of Science
Idioma: Inglês

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The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry

Kara-José, Andrea C ; Melo, Jr, Luiz Alberto S ; Esporcatte, Bruno L B ; Endo, Angelica T N H ; Leite, Mauro Toledo ; Tavares, Ivan Maynart Acott, Ted S.

United States: Public Library of Science

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