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Light-driven fine chemical production in yeast biohybrids

Guo, Junling ; Suástegui, Miguel ; Sakimoto, Kelsey K ; Moody, Vanessa M ; Xiao, Gao ; Nocera, Daniel G ; Joshi, Neel S

Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6416), p.813-816 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Light-driven fine chemical production in yeast biohybrids
Autor: Guo, Junling ; Suástegui, Miguel ; Sakimoto, Kelsey K ; Moody, Vanessa M ; Xiao, Gao ; Nocera, Daniel G ; Joshi, Neel S
Assuntos: Baking yeast ; Biosynthesis ; Biotechnology ; Carbon ; Chemical synthesis ; Chemicals ; Cofactors ; Decoupling ; Electronics industry ; Electrons ; Energy efficiency ; Fine chemicals ; Fungi ; Genetic engineering ; Genetically engineered microorganisms ; Hybrid systems ; Indium ; Industrial engineering ; Light ; Manufacturing engineering ; NADP ; NADPH-diaphorase ; Nanoparticles ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Organic chemistry ; Phosphides ; Reduction ; Regeneration ; Saccharomyces cerevisiae ; Shikimic acid ; Sugar ; Sugars ; Yeast
É parte de: Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6416), p.813-816
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Authors Contributions: J.G., M.S., and N.S.J. conceived of the idea. All authors performed research and/or analyzed data. J.G., M.S., N.S.J., K.K.S., and D.G.N. wrote and/or edited the manuscript.
Descrição: Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile chemical synthesis platforms by integrating the light-harvesting properties of semiconductors with the synthetic potential of biological cells. We have developed a modular bioinorganic hybrid platform that consists of highly efficient light-harvesting indium phosphide nanoparticles and genetically engineered , a workhorse microorganism in biomanufacturing. The yeast harvests photogenerated electrons from the illuminated nanoparticles and uses them for the cytosolic regeneration of redox cofactors. This process enables the decoupling of biosynthesis and cofactor regeneration, facilitating a carbon- and energy-efficient production of the metabolite shikimic acid, a common precursor for several drugs and fine chemicals. Our work provides a platform for the rational design of biohybrids for efficient biomanufacturing processes with higher complexity and functionality.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Light-driven fine chemical production in yeast biohybrids

Guo, Junling ; Suástegui, Miguel ; Sakimoto, Kelsey K ; Moody, Vanessa M ; Xiao, Gao ; Nocera, Daniel G ; Joshi, Neel S

United States: The American Association for the Advancement of Science

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