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Shared heritability and functional enrichment across six solid cancers

Jiang, Xia ; Finucane, Hilary K ; Schumacher, Fredrick R ; Lesseur, Corina ; Andrew, Angeline S ; Antonenkova, Natalia N ; Arnold, Susanne M ; Arun, Banu K ; Bandera, Elisa V ; Barnes, Daniel R ; Bickeböller, Heike ; Bien, Stephanie A ; Bogdanova, Natalia V ; Bolla, Manjeet K ; Brauch, Hiltrud ; Brenner, Hermann ; Brunet, Joan ; Burwinkel, Barbara ; Caligo, Maria A ; Campa, Daniele ; Carvalho, André L ; Chanock, Stephen J ; Claessens, Frank ; Clements, Judith ; Cunningham, Julie M ; Daly, Mary B ; deFazio, Anna ; Fasching, Peter A ; Fletcher, Olivia ; Fortner, Renée T ; Godwin, Andrew K ; Goldberg, Mark S ; Goodman, Gary ; Hillemanns, Peter ; Høgdall, Estrid ; Hunter, David J ; Idos, Gregory ; Ingles, Sue Ann ; Johansson, Mattias ; John, Esther M ; Kibel, Adam S ; Kiemeney, Lambertus A ; Kristensen, Vessela N ; Lazarus, Philip ; Le, Nhu D ; Lessel, Davor ; Li, Li ; Lindor, Noralane M ; Liu, Geoffrey ; Loupakis, Fotios ; Margolin, Sara ; McGuffog, Lesley ; MacInnis, Robert J ; Moysich, Kirsten B ; Mulligan, Anna Marie ; Newcomb, Lisa F ; Nussbaum, Robert L ; Osorio, Ana ; Pandha, Hardev ; Parsons, Michael T ; Peters, Wilbert H M ; Plaseska-Karanfilska, Dijana ; Pring, Miranda ; Prokofyeva, Darya ; Stefansson, Kari ; Rennert, Gad ; Risch, Harvey A ; Saloustros, Emmanouil ; Sandler, Dale P ; Schabath, Matthew B ; Schleutker, Johanna ; Schmidt, Marjanka K ; Setiawan, V Wendy ; Shen, Hongbing ; Siegel, Erin M ; Southey, Melissa C ; Stanford, Janet L ; Teare, M Dawn ; Bjørge, Line ; Tischkowitz, Marc ; Toland, Amanda E ; Travis, Ruth C ; Tung, Nadine ; Ulrich, Cornelia M ; Usmani, Nawaid ; Vachon, Celine M ; Wang, Qin ; Weinberg, Clarice R ; Weinstein, Stephanie ; West, Catharine M L ; White, Emily ; Whittemore, Alice S ; Woll, Penella ; Woods, Michael ; Zheng, Wei ; McKay, James ; Eeles, Rosalind A ; Gruber, Stephen B ; Price, Alkes L ; Amos, Christopher I

Nature communications, 2019, Vol.10 (1), p.431-23, Article 431 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Shared heritability and functional enrichment across six solid cancers
Autor: Jiang, Xia ; Finucane, Hilary K ; Schumacher, Fredrick R ; Lesseur, Corina ; Andrew, Angeline S ; Antonenkova, Natalia N ; Arnold, Susanne M ; Arun, Banu K ; Bandera, Elisa V ; Barnes, Daniel R ; Bickeböller, Heike ; Bien, Stephanie A ; Bogdanova, Natalia V ; Bolla, Manjeet K ; Brauch, Hiltrud ; Brenner, Hermann ; Brunet, Joan ; Burwinkel, Barbara ; Caligo, Maria A ; Campa, Daniele ; Carvalho, André L ; Chanock, Stephen J ; Claessens, Frank ; Clements, Judith ; Cunningham, Julie M ; Daly, Mary B ; deFazio, Anna ; Fasching, Peter A ; Fletcher, Olivia ; Fortner, Renée T ; Godwin, Andrew K ; Goldberg, Mark S ; Goodman, Gary ; Hillemanns, Peter ; Høgdall, Estrid ; Hunter, David J ; Idos, Gregory ; Ingles, Sue Ann ; Johansson, Mattias ; John, Esther M ; Kibel, Adam S ; Kiemeney, Lambertus A ; Kristensen, Vessela N ; Lazarus, Philip ; Le, Nhu D ; Lessel, Davor ; Li, Li ; Lindor, Noralane M ; Liu, Geoffrey ; Loupakis, Fotios ; Margolin, Sara ; McGuffog, Lesley ; MacInnis, Robert J ; Moysich, Kirsten B ; Mulligan, Anna Marie ; Newcomb, Lisa F ; Nussbaum, Robert L ; Osorio, Ana ; Pandha, Hardev ; Parsons, Michael T ; Peters, Wilbert H M ; Plaseska-Karanfilska, Dijana ; Pring, Miranda ; Prokofyeva, Darya ; Stefansson, Kari ; Rennert, Gad ; Risch, Harvey A ; Saloustros, Emmanouil ; Sandler, Dale P ; Schabath, Matthew B ; Schleutker, Johanna ; Schmidt, Marjanka K ; Setiawan, V Wendy ; Shen, Hongbing ; Siegel, Erin M ; Southey, Melissa C ; Stanford, Janet L ; Teare, M Dawn ; Bjørge, Line ; Tischkowitz, Marc ; Toland, Amanda E ; Travis, Ruth C ; Tung, Nadine ; Ulrich, Cornelia M ; Usmani, Nawaid ; Vachon, Celine M ; Wang, Qin ; Weinberg, Clarice R ; Weinstein, Stephanie ; West, Catharine M L ; White, Emily ; Whittemore, Alice S ; Woll, Penella ; Woods, Michael ; Zheng, Wei ; McKay, James ; Eeles, Rosalind A ; Gruber, Stephen B ; Price, Alkes L ; Amos, Christopher I
Assuntos: analyses identify ; Basic Medicine ; Breast ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - ethnology ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Cancer ; Cancer and Oncology ; Cancer och onkologi ; Case-Control Studies ; cell-types ; Clinical Medicine ; Colorectal carcinoma ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - ethnology ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Correlation ; Etiology ; Female ; genetic architecture ; Genetic Predisposition to Disease ; genome-wide association ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - ethnology ; Head and Neck Neoplasms - genetics ; Head and Neck Neoplasms - pathology ; Heritability ; Humans ; Inheritance Patterns ; Klinisk medicin ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - ethnology ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Male ; Medical and Health Sciences ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; mendelian ; Mental disorders ; Mental Disorders - ethnology ; Mental Disorders - genetics ; Mental Disorders - physiopathology ; Neck ; Neoplasm Proteins - genetics ; Obstetrics, Gynecology and Reproductive Medicine ; Ovarian cancer ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - ethnology ; Ovarian Neoplasms - genetics ; Ovarian Neoplasms - pathology ; partitioning heritability ; Phenotype ; Polymorphism, Single Nucleotide ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - ethnology ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - pathology ; randomization ; Regulatory sequences ; Reproduktionsmedicin och gynekologi ; risk-factors ; Smoking ; Smoking - ethnology ; Smoking - genetics ; Smoking - physiopathology ; Solid tumors ; Statistical analysis ; susceptibility loci ; White People
É parte de: Nature communications, 2019, Vol.10 (1), p.431-23, Article 431
Descrição: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0.57, p = 4.6 × 10 ), breast and ovarian cancer (r = 0.24, p = 7 × 10 ), breast and lung cancer (r = 0.18, p =1.5 × 10 ) and breast and colorectal cancer (r = 0.15, p = 1.1 × 10 ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Editor: England: Nature Publishing Group
Idioma: Inglês;Norueguês

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Shared heritability and functional enrichment across six solid cancers

England: Nature Publishing Group

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