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Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China

Wu, Shan ; Wu, Zhidan ; Chen, Manlian ; Zhong, Xiangbin ; Gu, Haoyan ; Du, Wenjing ; Liu, Weidong ; Lang, Li ; Wang, Junyi

BMC medical genomics, 2024-01, Vol.17 (1), p.18-18, Article 18 [Periódico revisado por pares]

England: BioMed Central Ltd

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Título:
Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China
Autor: Wu, Shan ; Wu, Zhidan ; Chen, Manlian ; Zhong, Xiangbin ; Gu, Haoyan ; Du, Wenjing ; Liu, Weidong ; Lang, Li ; Wang, Junyi
Assuntos: Biotechnology industry ; Case-Control Studies ; China - epidemiology ; Classification and regression tree (CART) ; Deafness, Noise induced ; Disease susceptibility ; Family medical history ; Genes ; Genetic analysis ; Genetic aspects ; Genetic diversity ; Genetic Predisposition to Disease ; Genetic Risk Score ; Genetic risk score (GRS) ; Genetic susceptibility ; Genotype ; Health risk assessment ; Hearing loss ; Hearing Loss, Noise-Induced - epidemiology ; Hearing Loss, Noise-Induced - genetics ; Hearing protection ; Hearing tests ; Humans ; Medical research ; Medicine, Experimental ; Middle Aged ; Noise ; Noise control ; Noise, Occupational ; Occupational diseases ; Occupational noise-induced hearing loss (NIHL) ; Polymorphism ; Polymorphism, Single Nucleotide ; Prediction models ; Receptor-Like Protein Tyrosine Phosphatases, Class 8 - genetics ; Risk assessment ; Risk factors ; Single nucleotide polymorphism (SNP) ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism
É parte de: BMC medical genomics, 2024-01, Vol.17 (1), p.18-18, Article 18
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: This study aimed to screen and validate noise-induced hearing loss (NIHL) associated single nucleotide polymorphisms (SNPs), construct genetic risk prediction models, and evaluate higher-order gene-gene, gene-environment interactions for NIHL in Chinese population. First, 83 cases and 83 controls were recruited and 60 candidate SNPs were genotyped. Then SNPs with promising results were validated in another case-control study (153 cases and 252 controls). NIHL-associated SNPs were identified by logistic regression analysis, and a genetic risk model was constructed based on the genetic risk score (GRS), and classification and regression tree (CART) analysis was used to evaluate interactions among gene-gene and gene-environment. Six SNPs in five genes were significantly associated with NIHL risk (p < 0.05). A positive dose-response relationship was found between GRS values and NIHL risk. CART analysis indicated that strongest interaction was among subjects with age ≥ 45 years and cumulative noise exposure ≥ 95 [dB(A)·years], without personal protective equipment, and carried GJB2 rs3751385 (AA/AB) and FAS rs1468063 (AA/AB) (OR = 10.038, 95% CI = 2.770, 47.792), compared with the referent group. CDH23, FAS, GJB2, PTPRN2 and SIK3 may be NIHL susceptibility genes. GRS values may be utilized in the evaluation of the cumulative effect of genetic risk for NIHL based on NIHL-associated SNPs. Gene-gene, gene-environment interaction patterns play an important role in the incidence of NIHL.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Interactions of genetic variations in FAS, GJB2 and PTPRN2 are associated with noise-induced hearing loss: a case-control study in China

Wu, Shan ; Wu, Zhidan ; Chen, Manlian ; Zhong, Xiangbin ; Gu, Haoyan ; Du, Wenjing ; Liu, Weidong ; Lang, Li ; Wang, Junyi

England: BioMed Central Ltd

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