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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

Garcés, Maria Fernanda ; Buell-Acosta, Julieth Daniela ; Rodríguez-Navarro, Haiver Antonio ; Pulido-Sánchez, Estefania ; Rincon-Ramírez, Juan José ; Moreno-Ordóñez, Diana Carolina ; Franco-Vega, Roberto ; Roncancio-Muñoz, Jhoan Sebastian ; Burgos-Cardenas, Alvaro Javier ; Lacunza, Ezequiel ; Castaño, Justo P ; Diéguez, Carlos ; Nogueiras, Rubén ; Sanchez, Elizabeth ; Caminos, Jorge Eduardo

Scientific reports, 2020-12, Vol.10 (1), p.21118-21118, Article 21118 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test
Autor: Garcés, Maria Fernanda ; Buell-Acosta, Julieth Daniela ; Rodríguez-Navarro, Haiver Antonio ; Pulido-Sánchez, Estefania ; Rincon-Ramírez, Juan José ; Moreno-Ordóñez, Diana Carolina ; Franco-Vega, Roberto ; Roncancio-Muñoz, Jhoan Sebastian ; Burgos-Cardenas, Alvaro Javier ; Lacunza, Ezequiel ; Castaño, Justo P ; Diéguez, Carlos ; Nogueiras, Rubén ; Sanchez, Elizabeth ; Caminos, Jorge Eduardo
Assuntos: Adiponectin ; Adipose tissue ; Angiopoietin ; Angiopoietin-like Proteins - blood ; Blood Glucose - metabolism ; Body fat ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - blood ; Dual energy X-ray absorptiometry ; Fasting ; Fasting - blood ; Glucose ; Glucose tolerance ; Glucose Tolerance Test ; Humans ; Insulin ; Insulin - blood ; Insulin Resistance ; Leptin ; Male ; Obesity - blood ; Obesity - complications ; Serum levels ; Young Adult
É parte de: Scientific reports, 2020-12, Vol.10 (1), p.21118-21118, Article 21118
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Descrição: This study aimed to determine ANGPTL3 serum levels in healthy young lean and obese non-diabetic men during an oral glucose tolerance test (OGTT) and correlate them with anthropometric, biochemical and hormonal parameters. A case-control study was carried out and 30 young obese non-diabetic (23.90 ± 3.84 years and BMI 37.92 ± 4.85 kg/m ) and 28 age-matched healthy lean (24.56 ± 3.50 years and BMI of 22.10 ± 1.72 kg/m ) men were included in this study. The primary outcome measures were serum basal ANGPTL3 and ANGPTL3-area under the curve (AUC) levels. The percentage of body fat was measured by dual-energy X-ray absorptiometry and biochemical, hormonal and insulin resistance indices were determined. Basal ANGPTL3 and ANGPTL3-AUC levels were significantly elevated (p < 0.05) in young obese subjects compared with lean subjects and were positively and significantly associated with different anthropometric measurements. Fasting ANGPTL3 serum levels were positively correlated with fasting insulin, leptin, Leptin/Adiponectin index and triglyceride-glucose index. Moreover, ANGPTL3-AUC was negatively correlated with Matsuda index. In this regard, chronically high ANGPTL3 levels in young obese subjects might favor triglyceride-rich lipoprotein clearance to replenish triglyceride stores by white adipose tissue rather than oxidative tissues.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Serum angiopoietin-like 3 levels are elevated in obese non diabetic men but are unaffected during an oral glucose tolerance test

England: Nature Publishing Group

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