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Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California

Deng, Xianding ; Gu, Wei ; Federman, Scot ; du Plessis, Louis ; Pybus, Oliver G ; Faria, Nuno R ; Wang, Candace ; Yu, Guixia ; Bushnell, Brian ; Pan, Chao-Yang ; Guevara, Hugo ; Sotomayor-Gonzalez, Alicia ; Zorn, Kelsey ; Gopez, Allan ; Servellita, Venice ; Hsu, Elaine ; Miller, Steve ; Bedford, Trevor ; Greninger, Alexander L ; Roychoudhury, Pavitra ; Starita, Lea M ; Famulare, Michael ; Chu, Helen Y ; Shendure, Jay ; Jerome, Keith R ; Anderson, Catie ; Gangavarapu, Karthik ; Zeller, Mark ; Spencer, Emily ; Andersen, Kristian G ; MacCannell, Duncan ; Paden, Clinton R ; Li, Yan ; Zhang, Jing ; Tong, Suxiang ; Armstrong, Gregory ; Morrow, Scott ; Willis, Matthew ; Matyas, Bela T ; Mase, Sundari ; Kasirye, Olivia ; Park, Maggie ; Masinde, Godfred ; Chan, Curtis ; Yu, Alexander T ; Chai, Shua J ; Villarino, Elsa ; Bonin, Brandon ; Wadford, Debra A ; Chiu, Charles Y

Science (American Association for the Advancement of Science), 2020-07, Vol.369 (6503), p.582-587 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California
Autor: Deng, Xianding ; Gu, Wei ; Federman, Scot ; du Plessis, Louis ; Pybus, Oliver G ; Faria, Nuno R ; Wang, Candace ; Yu, Guixia ; Bushnell, Brian ; Pan, Chao-Yang ; Guevara, Hugo ; Sotomayor-Gonzalez, Alicia ; Zorn, Kelsey ; Gopez, Allan ; Servellita, Venice ; Hsu, Elaine ; Miller, Steve ; Bedford, Trevor ; Greninger, Alexander L ; Roychoudhury, Pavitra ; Starita, Lea M ; Famulare, Michael ; Chu, Helen Y ; Shendure, Jay ; Jerome, Keith R ; Anderson, Catie ; Gangavarapu, Karthik ; Zeller, Mark ; Spencer, Emily ; Andersen, Kristian G ; MacCannell, Duncan ; Paden, Clinton R ; Li, Yan ; Zhang, Jing ; Tong, Suxiang ; Armstrong, Gregory ; Morrow, Scott ; Willis, Matthew ; Matyas, Bela T ; Mase, Sundari ; Kasirye, Olivia ; Park, Maggie ; Masinde, Godfred ; Chan, Curtis ; Yu, Alexander T ; Chai, Shua J ; Villarino, Elsa ; Bonin, Brandon ; Wadford, Debra A ; Chiu, Charles Y
Assuntos: BASIC BIOLOGICAL SCIENCES ; Betacoronavirus - genetics ; California - epidemiology ; Contact tracing ; Coronaviridae ; Coronavirus Infections - epidemiology ; Coronavirus Infections - transmission ; Coronavirus Infections - virology ; Coronaviruses ; COVID-19 ; Cruise ships ; Disease control ; Disease transmission ; Epidemics ; Epidemiological Monitoring ; Epidemiology ; Gene sequencing ; Genome, Viral ; Genomes ; Genomic analysis ; Humans ; Outbreaks ; Pandemics ; Phylogeny ; Pneumonia, Viral - epidemiology ; Pneumonia, Viral - transmission ; Pneumonia, Viral - virology ; Respiratory diseases ; SARS-CoV-2 ; Sequence Alignment ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Ships ; Travel ; Ultrasonic testing ; Viral diseases ; Virology ; Viruses ; Washington
É parte de: Science (American Association for the Advancement of Science), 2020-07, Vol.369 (6503), p.582-587
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Medical Research Council–São Paulo Research Foundation
USDOE Office of Science (SC)
AC02-05CH11231; R33-AI129455; K08-CA230156; 614725; 204311/Z/16/Z; MR/S0195/1; FAPESP-18/14389-0
National Institutes of Health (NIH)
European Research Council (ERC)
Royal Society
Wellcome Trust
These authors contributed equally to this work.
Descrição: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California

United States: The American Association for the Advancement of Science

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