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The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation

Valentini, Adriana ; Lubinski, Jan ; Byrski, Tomasz ; Ghadirian, Parviz ; Moller, Pal ; Lynch, Henry T. ; Ainsworth, Peter ; Neuhausen, Susan L. ; Weitzel, Jeffrey ; Singer, Christian F. ; Olopade, Olufunmilayo I. ; Saal, Howard ; Lyonnet, Dominique Stoppa ; Foulkes, William D. ; Kim-Sing, Charmaine ; Manoukian, Siranoush ; Zakalik, Dana ; Armel, Susan ; Senter, Leigha ; Eng, Charis ; Grunfeld, Eva ; Chiarelli, Anna M. ; Poll, Aletta ; Sun, Ping ; Narod, Steven A.

Breast cancer research and treatment, 2013-11, Vol.142 (1), p.177-185 [Periódico revisado por pares]

Boston: Springer US

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Título:
The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation
Autor: Valentini, Adriana ; Lubinski, Jan ; Byrski, Tomasz ; Ghadirian, Parviz ; Moller, Pal ; Lynch, Henry T. ; Ainsworth, Peter ; Neuhausen, Susan L. ; Weitzel, Jeffrey ; Singer, Christian F. ; Olopade, Olufunmilayo I. ; Saal, Howard ; Lyonnet, Dominique Stoppa ; Foulkes, William D. ; Kim-Sing, Charmaine ; Manoukian, Siranoush ; Zakalik, Dana ; Armel, Susan ; Senter, Leigha ; Eng, Charis ; Grunfeld, Eva ; Chiarelli, Anna M. ; Poll, Aletta ; Sun, Ping ; Narod, Steven A.
Assuntos: Analysis ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - genetics ; Breast Neoplasms - mortality ; Breast Neoplasms - therapy ; Cancer ; Case-Control Studies ; Cohort Studies ; Epidemiology ; Female ; Gene mutations ; Genes ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic aspects ; Gynecology. Andrology. Obstetrics ; Heterozygote ; Humans ; Mammary gland diseases ; Medical prognosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Multiple tumors. Solid tumors. Tumors in childhood (general aspects) ; Mutation ; Oncology ; Pregnancy ; Pregnant women ; Risk Factors ; Tumors
É parte de: Breast cancer research and treatment, 2013-11, Vol.142 (1), p.177-185
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Physicians are often approached by young women with a BRCA mutation and a recent history of breast cancer who wish to have a baby. They wish to know if pregnancy impacts upon their future risks of cancer recurrence and survival. To date, there is little information on the survival experience of women who carry a mutation in one of the BRCA genes and who become pregnant. From an international multi-center cohort study of 12,084 women with a BRCA1 or BRCA2 mutation, we identified 128 case subjects who were diagnosed with breast cancer while pregnant or who became pregnant after a diagnosis of breast cancer. These women were age-matched to 269 mutation carriers with breast cancer who did not become pregnant (controls). Subjects were followed from the date of breast cancer diagnosis until the date of last follow-up or death from breast cancer. The Kaplan–Meier method was used to estimate 15-year survival rates. The hazard ratio for survival associated with pregnancy was calculated using a left-truncated Cox proportional hazard model, adjusting for other prognostic factors. Among women who were diagnosed with breast cancer when pregnant or who became pregnant thereafter, the 15-year survival rate was 91.5 %, compared to a survival of 88.6 % for women who did not become pregnant (adjusted hazard ratio = 0.76; 95 % CI 0.31–1.91; p = 0.56). Pregnancy concurrent with or after a diagnosis of breast cancer does not appear to adversely affect survival among BRCA1/2 mutation carriers.
Editor: Boston: Springer US
Idioma: Inglês

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The impact of pregnancy on breast cancer survival in women who carry a BRCA1 or BRCA2 mutation

Boston: Springer US

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