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Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

Hoff, Nicole A ; Mukadi, Patrick ; Doshi, Reena H ; Bramble, Matthew S ; Lu, Kai ; Gadoth, Adva ; Sinai, Cyrus ; Spencer, D’Andre ; Nicholson, Bradley P ; Williams, Russell ; Mossoko, Matthias ; Ilunga-Kebela, Benoit ; Wasiswa, Joseph ; Okitolonda-Wemakoy, Emile ; Alfonso, Vivian H ; Steffen, Imke ; Muyembe-Tamfum, Jean-Jacques ; Simmons, Graham ; Rimoin, Anne W

The Journal of Infectious Diseases, 2019-01, Vol.219 (4), p.517-525

eScholarship, University of California

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Título:
Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo
Autor: Hoff, Nicole A ; Mukadi, Patrick ; Doshi, Reena H ; Bramble, Matthew S ; Lu, Kai ; Gadoth, Adva ; Sinai, Cyrus ; Spencer, D’Andre ; Nicholson, Bradley P ; Williams, Russell ; Mossoko, Matthias ; Ilunga-Kebela, Benoit ; Wasiswa, Joseph ; Okitolonda-Wemakoy, Emile ; Alfonso, Vivian H ; Steffen, Imke ; Muyembe-Tamfum, Jean-Jacques ; Simmons, Graham ; Rimoin, Anne W
Assuntos: 80 and over ; Adult ; Aged ; Antibodies ; Biodefense ; Biological Sciences ; Democratic Republic of the Congo ; Ebola virus ; Ebolavirus ; Emerging Infectious Diseases ; Female ; Good Health and Well Being ; Health Personnel ; healthcare workers ; Humans ; Immunoglobulin G ; Infection ; Infectious Diseases ; Male ; Medical and Health Sciences ; Microbiology ; Middle Aged ; Neutralizing ; Prevention ; Seroepidemiologic Studies ; serology ; Surveys and Questionnaires ; Vaccine Related ; Viral ; Young Adult
É parte de: The Journal of Infectious Diseases, 2019-01, Vol.219 (4), p.517-525
Notas: The Journal of Infectious Diseases, vol 219, iss 4
517 - 525
Descrição: Healthcare settings have played a major role in propagation of Ebola virus (EBOV) outbreaks. Healthcare workers (HCWs) have elevated risk of contact with EBOV-infected patients, particularly if safety precautions are not rigorously practiced. We conducted a serosurvey to determine seroprevalence against multiple EBOV antigens among HCWs of Boende Health Zone, Democratic Republic of the Congo, the site of a 2014 EBOV outbreak. Interviews and specimens were collected from 565 consenting HCWs. Overall, 234 (41.4%) of enrolled HCWs were reactive to at least 1 EBOV protein: 159 (28.1%) were seroreactive for anti-glycoprotein immunoglobulin G (IgG), 89 (15.8%) were seroreactive for anti-nucleoprotein IgG, and 54 (9.5%) were VP40 positive. Additionally, sera from 16 (2.8%) HCWs demonstrated neutralization capacity. These data demonstrate that a significant proportion of HCWs have the ability to neutralize virus, despite never having developed Ebola virus disease symptoms, highlighting an important and poorly documented aspect of EBOV infection and progression.
Editor: eScholarship, University of California
Idioma: Inglês

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Serologic Markers for Ebolavirus Among Healthcare Workers in the Democratic Republic of the Congo

eScholarship, University of California

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