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Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas

Martinho, Olga ; Granja, Sara ; Jaraquemada, Teresa ; Caeiro, Cláudia ; Miranda-Gonçalves, Vera ; Honavar, Mrinalini ; Costa, Paulo ; Damasceno, Margarida ; Rosner, Marsha R ; Lopes, José M ; Reis, Rui M Jones, Chris

PloS one, 2012-01, Vol.7 (1), p.e30769 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas
Autor: Martinho, Olga ; Granja, Sara ; Jaraquemada, Teresa ; Caeiro, Cláudia ; Miranda-Gonçalves, Vera ; Honavar, Mrinalini ; Costa, Paulo ; Damasceno, Margarida ; Rosner, Marsha R ; Lopes, José M ; Reis, Rui M
Jones, Chris
Assuntos: Adolescent ; Adult ; Aged ; Angiogenesis ; Animals ; Apoptosis ; Biology ; Biomarkers ; Biomarkers, Tumor - antagonists & inhibitors ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Biomarkers, Tumor - physiology ; Brain cancer ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Brain Neoplasms - metabolism ; Brain Neoplasms - mortality ; Brain research ; Brain tumors ; Breast cancer ; Cancer ; Cancer metastasis ; Cancer research ; Carcinogens ; Care and treatment ; Cascades ; Cell proliferation ; Cells, Cultured ; Chick Embryo ; Child ; Child, Preschool ; Development and progression ; Disease Progression ; Down-Regulation - genetics ; Endometrial cancer ; Female ; Gene Expression Regulation, Neoplastic - drug effects ; Glioma ; Glioma - diagnosis ; Glioma - genetics ; Glioma - metabolism ; Glioma - mortality ; Gliomas ; Health sciences ; Humans ; Intracellular signalling ; Invasiveness ; Kinases ; Laboratories ; Male ; Medical prognosis ; Medical research ; Medicine ; Melanoma ; Metastases ; Metastasis ; Middle Aged ; Molecular modelling ; Neoplasms ; Neovascularization, Physiologic - drug effects ; Oncology ; Oncology, Experimental ; Pathology ; Patients ; Phosphatidylethanolamine Binding Protein - antagonists & inhibitors ; Phosphatidylethanolamine Binding Protein - genetics ; Phosphatidylethanolamine Binding Protein - metabolism ; Phosphatidylethanolamine Binding Protein - physiology ; Prognosis ; Prostate cancer ; Protein expression ; Proteins ; Raf protein ; RNA, Small Interfering - pharmacology ; Transfection ; Tumors ; Viability ; Young Adult
É parte de: PloS one, 2012-01, Vol.7 (1), p.e30769
Notas: Conceived and designed the experiments: OM RR. Performed the experiments: OM SG TJ CC VM-G. Analyzed the data: OM MR RR. Contributed reagents/materials/analysis tools: MH PC MD JL. Wrote the paper: OM MR JL RR.
Descrição: Malignant gliomas are highly infiltrative and invasive tumors, which precludes the few treatment options available. Therefore, there is an urgent need to elucidate the molecular mechanisms underlying gliomas aggressive phenotype and poor prognosis. The Raf Kinase Inhibitory protein (RKIP), besides regulating important intracellular signaling cascades, was described to be associated with progression, metastasis and prognosis in several human neoplasms. Its role in the prognosis and tumourigenesis of gliomas remains unclear. In the present study, we found that RKIP protein is absent in a low frequency (10%, 20/193) of glioma tumors. Nevertheless, the absence of RKIP expression was an independent prognostic marker in glioma. Additionally, by in vitro downregulation of RKIP, we found that RKIP inhibition induces a higher viability and migration of the cells, having no effect on cellular proliferation and angiogenesis, as assessed by in vivo CAM assay. In conclusion, this is the largest series studied so far evaluating the expression levels of this important cancer suppressor protein in glioma tumors. Our results suggest that in a subset of tumors, the absence of RKIP associates with highly malignant behavior and poor survival of patients, which may be a useful biomarker for tailored treatment of glioma patients.
Editor: United States: Public Library of Science
Idioma: Inglês

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Downregulation of RKIP is associated with poor outcome and malignant progression in gliomas

Martinho, Olga ; Granja, Sara ; Jaraquemada, Teresa ; Caeiro, Cláudia ; Miranda-Gonçalves, Vera ; Honavar, Mrinalini ; Costa, Paulo ; Damasceno, Margarida ; Rosner, Marsha R ; Lopes, José M ; Reis, Rui M Jones, Chris

United States: Public Library of Science

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